Comparative Study
doi: 10.1126/science.4071057.
Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies
- PMID: 4071057
- DOI: 10.1126/science.4071057
Item in Clipboard
Comparative Study
Brain-derived acidic fibroblast growth factor: complete amino acid sequence and homologies
Science.
.
Abstract
Bovine brain-derived acidic fibroblast growth factor (aFGF) is a protein mitogen originally identified in partially purified preparations of whole brain. The protein was purified to homogeneity and shown to be a potent vascular endothelial cell mitogen in culture and angiogenic substance in vivo. The homology of aFGF to human interleukin-1 beta was inferred from partial sequence data. The complete amino acid sequence of aFGF has now been determined and observed to be similar to both basic FGF and interleukin-1's. A neuropeptide-like sequence, flanked by basic dipeptides, was observed within the aFGF sequence.
Similar articles
-
Primary structure of bovine brain acidic fibroblast growth factor (FGF).Biochem Biophys Res Commun. 1985 Dec 17;133(2):554-62. doi: 10.1016/0006-291x(85)90942-8. Biochem Biophys Res Commun. 1985. PMID: 4084288
-
The complete amino acid sequence of human brain-derived acidic fibroblast growth factor.Biochem Biophys Res Commun. 1986 Jul 31;138(2):611-7. doi: 10.1016/s0006-291x(86)80540-x. Biochem Biophys Res Commun. 1986. PMID: 3527167
-
Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1.Proc Natl Acad Sci U S A. 1985 Oct;82(19):6409-13. doi: 10.1073/pnas.82.19.6409. Proc Natl Acad Sci U S A. 1985. PMID: 2413439 Free PMC article.
-
Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.Proc Natl Acad Sci U S A. 1985 Oct;82(19):6507-11. doi: 10.1073/pnas.82.19.6507. Proc Natl Acad Sci U S A. 1985. PMID: 3863109 Free PMC article.
-
Human brain-derived acidic and basic fibroblast growth factors: amino terminal sequences and specific mitogenic activities.Biochem Biophys Res Commun. 1986 Mar 13;135(2):541-8. doi: 10.1016/0006-291x(86)90028-8. Biochem Biophys Res Commun. 1986. PMID: 3964259
Cited by
-
Multiple forms of basic fibroblast growth factor: amino-terminal cleavages by tumor cell- and brain cell-derived acid proteinases.Proc Natl Acad Sci U S A. 1987 Apr;84(7):1839-43. doi: 10.1073/pnas.84.7.1839. Proc Natl Acad Sci U S A. 1987. PMID: 3031655 Free PMC article.
-
Production of a recombinant human basic fibroblast growth factor with a collagen binding domain.Protoplasma. 2001;218(1-2):95-103. doi: 10.1007/BF01288365. Protoplasma. 2001. PMID: 11732325
-
Basic fibroblast growth factor is a substrate for protein phosphorylation and is phosphorylated by capillary endothelial cells in culture.Proc Natl Acad Sci U S A. 1989 May;86(9):3174-8. doi: 10.1073/pnas.86.9.3174. Proc Natl Acad Sci U S A. 1989. PMID: 2541433 Free PMC article.
-
Three-dimensional structure of human basic fibroblast growth factor.Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3441-5. doi: 10.1073/pnas.88.8.3441. Proc Natl Acad Sci U S A. 1991. PMID: 1707542 Free PMC article.
-
Structural evidence that endothelial cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor.Proc Natl Acad Sci U S A. 1986 Oct;83(19):7216-20. doi: 10.1073/pnas.83.19.7216. Proc Natl Acad Sci U S A. 1986. PMID: 3532107 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
