Clinical Trial
doi: 10.1002/sim.4780040304.
Assessing apparent treatment--covariate interactions in randomized clinical trials
- PMID: 4059716
- DOI: 10.1002/sim.4780040304
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Clinical Trial
Assessing apparent treatment--covariate interactions in randomized clinical trials
Stat Med.
1985 Jul-Sep.
Abstract
In the context of clinical trials, a qualitative treatment--covariate interaction occurs when a patient's preferred treatment depends on his covariates. In this paper I review the nature and interpretation of various kinds of interactions, compare the use of overall tests for interaction to subset analysis, present some examples of apparent treatment-covariate interactions that have arisen in actual randomized clinical trials, and discuss some recent work by others related to significance testing, estimation and assessment of apparent treatment-covariate interactions.
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