doi: 10.1016/0022-2836(85)90077-4.
Improved free energies for G.C base-pairs
- PMID: 4057259
- DOI: 10.1016/0022-2836(85)90077-4
Item in Clipboard
Improved free energies for G.C base-pairs
J Mol Biol.
.
Abstract
Thermodynamic parameters of helix formation are reported for seven oligoribonucleotides containing only G.C pairs. These data are used with the nearest-neighbor model to calculate enthalpies and free energies of base-pair formation for G.C pairs. For helix initiation, the free energy change at 37 degrees C, delta G(0)37, is +3.9 kcal/mol; for helix propagation, the delta G(0)37 values are -2.3, -3.2 and -3.3 kcal/mol for C-G, G-G and G-C neighbors, respectively.
Similar articles
-
Free energy contributions of G.U and other terminal mismatches to helix stability.Biochemistry. 1986 Jun 3;25(11):3209-13. doi: 10.1021/bi00359a019. Biochemistry. 1986. PMID: 3730356
-
Stability of RNA hairpins closed by wobble base pairs.Biochemistry. 1998 Jan 27;37(4):1094-100. doi: 10.1021/bi972050v. Biochemistry. 1998. PMID: 9454601
-
Sequence dependence of the stability of RNA hairpin molecules with six nucleotide loops.Biochemistry. 2006 Feb 7;45(5):1400-7. doi: 10.1021/bi051750u. Biochemistry. 2006. PMID: 16445282
-
Nearest-neighbor parameters for G.U mismatches: [formula; see text] is destabilizing in the contexts [formula; see text] and [formula; see text] but stabilizing in [formula; see text].Biochemistry. 1991 Nov 19;30(46):11124-32. doi: 10.1021/bi00110a015. Biochemistry. 1991. PMID: 1718426
-
Thermodynamic studies of RNA stability.J Biomol Struct Dyn. 1984 Mar;1(5):1229-42. doi: 10.1080/07391102.1984.10507514. J Biomol Struct Dyn. 1984. PMID: 6086053 Review.
Cited by
-
Developing an Updated Strategy for Estimating the Free-Energy Parameters in RNA Duplexes.Int J Mol Sci. 2021 Sep 8;22(18):9708. doi: 10.3390/ijms22189708. Int J Mol Sci. 2021. PMID: 34575896 Free PMC article.
-
Revision of AMBER Torsional Parameters for RNA Improves Free Energy Predictions for Tetramer Duplexes with GC and iGiC Base Pairs.J Chem Theory Comput. 2012 Jan 10;8(1):172-181. doi: 10.1021/ct200557r. Epub 2011 Dec 1. J Chem Theory Comput. 2012. PMID: 22249447 Free PMC article.
-
Theoretical Analysis of a Self-Replicator With Reduced Template Inhibition Based on an Informational Leaving Group.J Mol Evol. 2016 Mar;82(2-3):93-109. doi: 10.1007/s00239-016-9733-0. Epub 2016 Mar 22. J Mol Evol. 2016. PMID: 27002711
-
Testing the nearest neighbor model for canonical RNA base pairs: revision of GU parameters.Biochemistry. 2012 Apr 24;51(16):3508-22. doi: 10.1021/bi3002709. Epub 2012 Apr 10. Biochemistry. 2012. PMID: 22490167 Free PMC article.
-
Improved free-energy parameters for predictions of RNA duplex stability.Proc Natl Acad Sci U S A. 1986 Dec;83(24):9373-7. doi: 10.1073/pnas.83.24.9373. Proc Natl Acad Sci U S A. 1986. PMID: 2432595 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
