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. 1985 Aug 22;836(1):143-52.
doi: 10.1016/0005-2760(85)90230-9.

Sex-specific difference of the galabiosylceramide level in the glycosphingolipids of human thyroid

B Bouchon, J Portoukalian, H Bornet

Sex-specific difference of the galabiosylceramide level in the glycosphingolipids of human thyroid

B Bouchon et al. Biochim Biophys Acta. .

Abstract

The glycosphingolipids of human thyroid were isolated and characterized by gas-liquid chromatography and sequential enzymic hydrolysis. The major purified components were identified as glucosyl- and galactosyl-ceramides, lactosyl- and galabiosylceramides, globotriaosyl- and globotetraosylceramides. The long-chain base analyses showed a high proportion of phytosphingosine in glycosylceramide and galabiosylceramide. Fatty acids in 22:0, 24:0, 24:1 prevailed, especially in the cerebroside fraction, with a significant content of alpha-hydroxylated species in galactosylceramide. Female thyroid had a very low content of galabiosylceramide and a higher content of glucosylceramide, as compared to male. No significant difference was found in the other neutral glycosphingolipids and gangliosides.

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