doi: 10.1126/science.4001928.
Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation
- PMID: 4001928
- DOI: 10.1126/science.4001928
Item in Clipboard
Involvement of sialic acid on endothelial cells in organ-specific lymphocyte recirculation
Science.
.
Abstract
Mouse lymphocytes incubated on cryostat-cut sections of lymphoid organs (lymph nodes and Peyer's patches) specifically adhere to the endothelium of high endothelial venules (HEV), the specialized blood vessels to which recirculating lymphocytes attach as they migrate from the blood into the parenchyma of the lymphoid organs. Treatment of sections with sialidase eliminated the binding of lymphocytes to peripheral lymph node HEV, had no effect on binding to Peyer's patch HEV, and had an intermediate effect on mesenteric lymph node HEV. These results suggest that sialic acid on endothelial cells may be an organ-specific recognition determinant for lymphocyte attachment.
Similar articles
-
Organ specificity of lymphocyte migration: mediation by highly selective lymphocyte interaction with organ-specific determinants on high endothelial venules.Eur J Immunol. 1980 Jul;10(7):556-61. doi: 10.1002/eji.1830100713. Eur J Immunol. 1980. PMID: 6157544
-
Intravenously injected sialidase inactivates attachment sites for lymphocytes on high endothelial venules.J Immunol. 1989 Mar 15;142(6):1895-902. J Immunol. 1989. PMID: 2921520
-
Requirement for sialic acid on the endothelial ligand of a lymphocyte homing receptor.J Cell Biol. 1990 Dec;111(6 Pt 1):2757-64. doi: 10.1083/jcb.111.6.2757. J Cell Biol. 1990. PMID: 2277086 Free PMC article.
-
Integrins and L-selectin in lymphocyte-endothelium interactions and homing into gut-associated tissue.Behring Inst Mitt. 1993 Aug;(92):30-5. Behring Inst Mitt. 1993. PMID: 7504455 Review.
-
Integrin molecules involved in lymphocyte homing to Peyer's patches.Immunol Rev. 1989 Apr;108:45-61. doi: 10.1111/j.1600-065x.1989.tb00012.x. Immunol Rev. 1989. PMID: 2670742 Review.
Cited by
-
Salivary mucin MUC7 oligosaccharides in patients with recurrent aphthous stomatitis.Clin Oral Investig. 2015 Nov;19(8):2147-52. doi: 10.1007/s00784-015-1495-3. Epub 2015 Jun 9. Clin Oral Investig. 2015. PMID: 26051835 Clinical Trial.
-
High endothelial differentiation in human lymphoid and inflammatory tissues defined by monoclonal antibody HECA-452.Am J Pathol. 1988 Jan;130(1):147-55. Am J Pathol. 1988. PMID: 3276207 Free PMC article.
-
Phosphomannosyl-derivatized beads detect a receptor involved in lymphocyte homing.J Cell Biol. 1987 Mar;104(3):713-23. doi: 10.1083/jcb.104.3.713. J Cell Biol. 1987. PMID: 2950121 Free PMC article.
-
Isolation and characterization from porcine serum of a soluble sulfotransferase responsible for 6-O-sulfation of the galactose residue in 2'-fucosyllactose: implications in the synthesis of the ligand for L-selectin.Glycoconj J. 1999 Jul;16(7):357-63. doi: 10.1023/a:1007052228230. Glycoconj J. 1999. PMID: 10619708
-
Reversible stimulation of lymphocyte motility by cultured high endothelial cells: mediation by L-selectin.Immunology. 1995 Jan;84(1):47-54. Immunology. 1995. PMID: 7534263 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
