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. 1985 Jun;54(3):764-72.
doi: 10.1128/JVI.54.3.764-772.1985.

Nucleotide sequence of a full-length human endogenous retroviral segment

R Repaske, P E Steele, R R O'Neill, A B Rabson, M A Martin

Nucleotide sequence of a full-length human endogenous retroviral segment

R Repaske et al. J Virol. 1985 Jun.

Abstract

The nucleotide sequence of a full-length (8.8-kilobase) endogenous C-type human retroviral DNA (clone 4-1) is presented and compared with that of Moloney murine leukemia virus (MoMuLV) DNA. Colinearity of deduced amino acids of clone 4-1 with MoMuLV in the gag and pol regions was clearly evident, and overall amino acid homology in these regions was about 40%. Identification of the putative N terminus of gag and p30, the gag-pol junction, and the C terminus of pol could be established on the basis of sequence homology with MoMuLV. Unique characteristics of the endogenous human retroviral DNA included a tRNA Glu primer binding site separated from the 5' long terminal repeat by a pentanucleotide and a putative env sequence which does not appear to overlap the C terminus of pol and has virtually no homology with the env gene of known infectious retroviruses. Clone 4-1 represents a defective prototype of a human C-type retrovirus which integrated into the germ line some time in the distant past.

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