Codon usage and tRNA content in unicellular and multicellular organisms
- PMID: 3916708
- DOI: 10.1093/oxfordjournals.molbev.a040335
Codon usage and tRNA content in unicellular and multicellular organisms
Abstract
Choices of synonymous codons in unicellular organisms are here reviewed, and differences in synonymous codon usages between Escherichia coli and the yeast Saccharomyces cerevisiae are attributed to differences in the actual populations of isoaccepting tRNAs. There exists a strong positive correlation between codon usage and tRNA content in both organisms, and the extent of this correlation relates to the protein production levels of individual genes. Codon-choice patterns are believed to have been well conserved during the course of evolution. Examination of silent substitutions and tRNA populations in Enterobacteriaceae revealed that the evolutionary constraint imposed by tRNA content on codon usage decelerated rather than accelerated the silent-substitution rate, at least insofar as pairs of taxonomically related organisms were examined. Codon-choice patterns of multicellular organisms are briefly reviewed, and diversity in G+C percentage at the third position of codons in vertebrate genes--as well as a possible causative factor in the production of this diversity--is discussed.
Similar articles
-
Coevolution of codon usage and transfer RNA abundance.Nature. 1987 Feb 19-25;325(6106):728-30. doi: 10.1038/325728a0. Nature. 1987. PMID: 2434856
-
Studies of codon usage and tRNA genes of 18 unicellular organisms and quantification of Bacillus subtilis tRNAs: gene expression level and species-specific diversity of codon usage based on multivariate analysis.Gene. 1999 Sep 30;238(1):143-55. doi: 10.1016/s0378-1119(99)00225-5. Gene. 1999. PMID: 10570992
-
Correlation between the abundance of yeast transfer RNAs and the occurrence of the respective codons in protein genes. Differences in synonymous codon choice patterns of yeast and Escherichia coli with reference to the abundance of isoaccepting transfer RNAs.J Mol Biol. 1982 Jul 15;158(4):573-97. doi: 10.1016/0022-2836(82)90250-9. J Mol Biol. 1982. PMID: 6750137 No abstract available.
-
The Yin and Yang of codon usage.Hum Mol Genet. 2016 Oct 1;25(R2):R77-R85. doi: 10.1093/hmg/ddw207. Epub 2016 Jun 27. Hum Mol Genet. 2016. PMID: 27354349 Free PMC article. Review.
-
DNA sequence evolution: the sounds of silence.Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29;349(1329):241-7. doi: 10.1098/rstb.1995.0108. Philos Trans R Soc Lond B Biol Sci. 1995. PMID: 8577834 Review.
Cited by
-
Mutations in the pqe-1 gene enhance transgene expression in Caenorhabditis elegans.G3 (Bethesda). 2012 Jul;2(7):741-51. doi: 10.1534/g3.112.002832. Epub 2012 Jul 1. G3 (Bethesda). 2012. PMID: 22870397 Free PMC article.
-
No Evidence that Selection on Synonymous Codon Usage Affects Patterns of Protein Evolution in Bacteria.Genome Biol Evol. 2024 Feb 1;16(2):evad232. doi: 10.1093/gbe/evad232. Genome Biol Evol. 2024. PMID: 38149940 Free PMC article.
-
The genome of the obligate intracellular parasite Trachipleistophora hominis: new insights into microsporidian genome dynamics and reductive evolution.PLoS Pathog. 2012;8(10):e1002979. doi: 10.1371/journal.ppat.1002979. Epub 2012 Oct 25. PLoS Pathog. 2012. PMID: 23133373 Free PMC article.
-
Anti-infective immunoadhesins from plants.Plant Biotechnol J. 2015 Oct;13(8):1078-93. doi: 10.1111/pbi.12441. Epub 2015 Aug 4. Plant Biotechnol J. 2015. PMID: 26242703 Free PMC article. Review.
-
The interface of protein structure, protein biophysics, and molecular evolution.Protein Sci. 2012 Jun;21(6):769-85. doi: 10.1002/pro.2071. Epub 2012 Apr 23. Protein Sci. 2012. PMID: 22528593 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
