Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies

doi:10.1007/978-3-031-57165-7_14

Review

. 2024:1451:219-237.

doi: 10.1007/978-3-031-57165-7_14.

Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies

Shailendra Dwivedi¹, Vijay Singh², Ruchika Agrawal³, Radhieka Misra⁴, Sadashiv⁵, Ghizal Fatima⁶, Afroz Abidi⁷, Sanjeev Misra⁸

Affiliations

¹ Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008, India. tarang2016@gmail.com.
² Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
³ Department of ENT, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
⁴ Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁵ Department of Biochemistry, All India Institute of Medical Sciences, Raebareli, 229405, India.
⁶ Department of Biotechnology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁷ Department of Pharmacology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁸ Atal Bihari Bajpayee Medical University, Lucknow, 225001, India.

PMID: 38801581
DOI: 10.1007/978-3-031-57165-7_14

Review

Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies

Shailendra Dwivedi et al. Adv Exp Med Biol. 2024.

. 2024:1451:219-237.

doi: 10.1007/978-3-031-57165-7_14.

Authors

Shailendra Dwivedi¹, Vijay Singh², Ruchika Agrawal³, Radhieka Misra⁴, Sadashiv⁵, Ghizal Fatima⁶, Afroz Abidi⁷, Sanjeev Misra⁸

Affiliations

¹ Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008, India. tarang2016@gmail.com.
² Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
³ Department of ENT, All India Institute of Medical Sciences, Gorakhpur, 273008, India.
⁴ Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁵ Department of Biochemistry, All India Institute of Medical Sciences, Raebareli, 229405, India.
⁶ Department of Biotechnology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁷ Department of Pharmacology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, India.
⁸ Atal Bihari Bajpayee Medical University, Lucknow, 225001, India.

PMID: 38801581
DOI: 10.1007/978-3-031-57165-7_14

Abstract

The monkeypox virus (MPXV), responsible for human disease, has historically been limited to the African countries, with only a few isolated instances reported elsewhere in the world. Nevertheless, in recent years, there have been occurrences of monkeypox in regions where the disease is typically absent, which has garnered global interest. Within a period of less than four months, the incidence of MPXV infections has surged to over 48,000 cases, resulting in a total of 13 deaths. This chapter has addressed the genetics of the pox virus, specifically the human monkeypox virus, and its interaction with the immune systems of host organisms. The present chapter is skillfully constructed, encompassing diagnostic methodologies that span from traditional to developing molecular techniques. Furthermore, the chapter provides a succinct analysis of the therapeutic methods employed, potential future developments, and the various emerging difficulties encountered in illness management.

Keywords: Adaptive immunity; Diagnostics; Genomics; Host immunity; Human monkeypox virus; Innate immunity; Treatments.

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Cited by

Innate Immune Response to Monkeypox Virus Infection: Mechanisms and Immune Escape.
Parnian R, Heydarifard F, Mousavi FS, Heydarifard Z, Zandi M. Parnian R, et al. J Innate Immun. 2024;16(1):413-424. doi: 10.1159/000540815. Epub 2024 Aug 13. J Innate Immun. 2024. PMID: 39137733 Free PMC article. Review.

References

1. Ali Y, Imtiaz H, Tahir MM et al (2023) Fragment-based approaches identified Tecovirimat-competitive novel drug candidate for targeting the F13 protein of the monkeypox virus. Viruses 15(2):570. https://doi.org/10.3390/v15020570 - DOI - PubMed - PMC
1. Ando J, Ngo MC, Ando M et al (2020) Identification of protective T-cell antigens for smallpox vaccines. Cytotherapy 22(11):642–652 - DOI - PubMed - PMC
1. Baker RO, Bray M, Huggins JW (2003) Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res 57(1–2):13–23 - DOI - PubMed - PMC
1. Berthet N, Descorps-Declère S, Besombes C et al (2021) Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018. Sci Rep 11(1):13085. https://doi.org/10.1038/s41598-021-92315-8 - DOI - PubMed - PMC
1. Bertran M, Andrews N, Davison C et al (2023) Effectiveness of one dose of MVA-BN smallpox vaccine against mpox in England using the case-coverage method: an observational study. Lancet Infect Dis S1473–3099(23):00057–00059. https://doi.org/10.1016/S1473-3099(23)00057-9 - DOI

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[1] Ali Y, Imtiaz H, Tahir MM et al (2023) Fragment-based approaches identified Tecovirimat-competitive novel drug candidate for targeting the F13 protein of the monkeypox virus. Viruses 15(2):570. https://doi.org/10.3390/v15020570 - DOI - PubMed - PMC

[2] Ali Y, Imtiaz H, Tahir MM et al (2023) Fragment-based approaches identified Tecovirimat-competitive novel drug candidate for targeting the F13 protein of the monkeypox virus. Viruses 15(2):570. https://doi.org/10.3390/v15020570 - DOI - PubMed - PMC

[3] Ando J, Ngo MC, Ando M et al (2020) Identification of protective T-cell antigens for smallpox vaccines. Cytotherapy 22(11):642–652 - DOI - PubMed - PMC

[4] Ando J, Ngo MC, Ando M et al (2020) Identification of protective T-cell antigens for smallpox vaccines. Cytotherapy 22(11):642–652 - DOI - PubMed - PMC

[5] Baker RO, Bray M, Huggins JW (2003) Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res 57(1–2):13–23 - DOI - PubMed - PMC

[6] Baker RO, Bray M, Huggins JW (2003) Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res 57(1–2):13–23 - DOI - PubMed - PMC

[7] Berthet N, Descorps-Declère S, Besombes C et al (2021) Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018. Sci Rep 11(1):13085. https://doi.org/10.1038/s41598-021-92315-8 - DOI - PubMed - PMC

[8] Berthet N, Descorps-Declère S, Besombes C et al (2021) Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018. Sci Rep 11(1):13085. https://doi.org/10.1038/s41598-021-92315-8 - DOI - PubMed - PMC

[9] Bertran M, Andrews N, Davison C et al (2023) Effectiveness of one dose of MVA-BN smallpox vaccine against mpox in England using the case-coverage method: an observational study. Lancet Infect Dis S1473–3099(23):00057–00059. https://doi.org/10.1016/S1473-3099(23)00057-9 - DOI

[10] Bertran M, Andrews N, Davison C et al (2023) Effectiveness of one dose of MVA-BN smallpox vaccine against mpox in England using the case-coverage method: an observational study. Lancet Infect Dis S1473–3099(23):00057–00059. https://doi.org/10.1016/S1473-3099(23)00057-9 - DOI

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Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies

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Human Monkeypox Virus and Host Immunity: New Challenges in Diagnostics and Treatment Strategies

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