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. 1985 Aug;82(15):4896-9.
doi: 10.1073/pnas.82.15.4896.

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells

C Dani, N Mechti, M Piechaczyk, B Lebleu, P Jeanteur, J M Blanchard

Increased rate of degradation of c-myc mRNA in interferon-treated Daudi cells

C Dani et al. Proc Natl Acad Sci U S A. 1985 Aug.

Abstract

The recent observation made in our laboratory that cellular myc (c-myc) mRNA has a very short half-life in a variety of normal and transformed human cells emphasized the potential importance of post-transcriptional regulation of c-myc gene expression. Jonak and Knight [Jonak, G. J. & Knight, E., Jr. (1984) Proc. Natl. Acad. Sci. USA 81, 1747-1750] have reported a selective reduction of c-myc mRNA accumulation in lymphoblastoid Daudi cells treated with human beta interferon. This provided a suitable situation in which to examine a possible action of negative modulators of c-myc expression at the level of mRNA stability. Our results confirm the observation by Jonak and Knight that c-myc mRNA level is depressed in cells treated with beta interferon and extend it to alpha 2 interferon. Furthermore, we now demonstrate that interferon has no effect on c-myc transcription rate in isolated nuclei but rather reduces the half-life of its mRNA. Conversely, we show that it increases the level of HLA-A2 mRNA by stimulating its transcription.

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