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. 2024 Jan 17;150(1):13.
doi: 10.1007/s00432-023-05527-y.

An update of predictive biomarkers related to WEE1 inhibition in cancer therapy

Zizhuo Wang #  1 , Wenting Li #  2 , Fuxia Li  2 , Rourou Xiao  3
Affiliations

An update of predictive biomarkers related to WEE1 inhibition in cancer therapy

Zizhuo Wang et al. J Cancer Res Clin Oncol. .

Abstract

Purpose: WEE1 is a crucial kinase involved in the regulation of G2/M checkpoint within the cell cycle. This article aims to comprehensively review the existing knowledge on the implication of WEE1 as a therapeutic target in tumor progression and drug resistance. Furthermore, we summarize the current predictive biomarkers employed to treat cancer with WEE1 inhibitors.

Methods: A systematic review of the literature was conducted to analyze the association between WEE1 inhibition and cancer progression, including tumor advancement and drug resistance. Special attention was paid to the identification and utilization of predictive biomarkers related to therapeutic response to WEE1 inhibitors.

Results: The review highlights the intricate involvement of WEE1 in tumor progression and drug resistance. It synthesizes the current knowledge on predictive biomarkers employed in WEE1 inhibitor treatments, offering insights into their prognostic significance. Notably, the article elucidates the potential for precision medicine by understanding these biomarkers in the context of tumor treatment outcomes.

Conclusion: WEE1 plays a pivotal role in tumor progression and is a promising therapeutic target. Distinguishing patients that would benefit from WEE1 inhibition will be a major direction of future research.

Keywords: Biomarkers; Cancer therapy; WEE1 inhibition.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Cell cycle checkpoint regulation mechanism. A Cell cycle regulation in cells with intact cell cycle checkpoint function when DNA damage occurs; B Cell cycle regulation after G1/S checkpoint deficiency combined with WEE1 inhibition
Fig. 2
Fig. 2
Biomarkers of sensitivity to WEE1 inhibition therapy
Fig. 3
Fig. 3
Biomarkers of resistance to WEE1 inhibition therapy
See this image and copyright information in PMC

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