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Comparative Study
. 1986;33(4):417-21.

Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors

A Mamytbeková, K Rezábek, H Kacerovská, J Grimová, J Svobodová
  • PMID: 3762804
Comparative Study

Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors

A Mamytbeková et al. Neoplasma. 1986.

Abstract

In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline). Flurbiprofen decreased significantly spontaneous metastases formation in a dose-depending manner. From the results obtained, it appears that the treatment with flurbiprofen, either on days 1-8 or days 1-21, was similarly effective. In mopidamole treated groups the number of animals with lung metastases was significantly decreased. This effect was not observed after treatment with dipyridamole or pentoxifylline.

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