Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen
- PMID: 3757029
- DOI: 10.1016/0092-8674(86)90073-5
Identification of a 160,000 dalton platelet membrane protein that mediates the initial divalent cation-dependent adhesion of platelets to collagen
Abstract
Platelets initially adhere to collagen via a divalent cation-dependent process supported by Mg2+, Mn2+, Fe2+, Cu2+, Zn2+, or Co2+ more rapidly and to a greater extent than by previously studied divalent cation-independent mechanisms. Ca2+ not only fails to support adhesion, it is inhibitory. Platelet activation and secretion are not required for adhesion by this mechanism. Monomeric and fibrillar collagens, but not denatured collagen, effectively support divalent cation-dependent adhesion. Types I, III, and IV collagen, but not type V collagen, support adhesion. A platelet surface protein of Mr 160,000, possibly identical with platelet membrane glycoprotein Ia, that binds to collagen with the appropriate divalent cation specificity has been identified and is the likely mediator of the initial divalent cation-dependent adhesion of platelets to collagen.
Similar articles
-
Platelet adhesion to native type I collagen fibrils. Role of GPVI in divalent cation-dependent and -independent adhesion and thromboxane A2 generation.J Biol Chem. 1998 Feb 20;273(8):4338-44. doi: 10.1074/jbc.273.8.4338. J Biol Chem. 1998. PMID: 9468482
-
Platelet adhesion and signaling induced by the octapeptide primary binding sequence (KOGEOGPK) from type III collagen.FASEB J. 2004 Sep;18(12):1339-47. doi: 10.1096/fj.03-1151com. FASEB J. 2004. PMID: 15333577
-
High-speed platelet adhesion under conditions of rapid flow.Proc Natl Acad Sci U S A. 1992 Jul 1;89(13):5754-8. doi: 10.1073/pnas.89.13.5754. Proc Natl Acad Sci U S A. 1992. PMID: 1631056 Free PMC article.
-
Platelet adhesion.Prog Hemost Thromb. 1984;7:211-88. Prog Hemost Thromb. 1984. PMID: 6397767 Review.
-
Platelet-reactivity of isolated constituents of the blood vessel wall.Haemostasis. 1979;8(3-5):158-70. doi: 10.1159/000214308. Haemostasis. 1979. PMID: 389755 Review.
Cited by
-
Decreased expression of integrin adhesive protein receptors in adenocarcinoma of the breast.Am J Pathol. 1990 Oct;137(4):863-70. Am J Pathol. 1990. PMID: 2221016 Free PMC article.
-
The thrombotic potential of oral pathogens.J Oral Microbiol. 2009 Aug 26;1. doi: 10.3402/jom.v1i0.1999. J Oral Microbiol. 2009. PMID: 21523210 Free PMC article.
-
Novel collectin/C1q receptor mediates mast cell activation and innate immunity.Blood. 2006 Jan 1;107(1):143-50. doi: 10.1182/blood-2005-06-2218. Epub 2005 Sep 15. Blood. 2006. PMID: 16166590 Free PMC article.
-
Arterial thrombosis--insidious, unpredictable and deadly.Nat Med. 2011 Nov 7;17(11):1423-36. doi: 10.1038/nm.2515. Nat Med. 2011. PMID: 22064432 Review.
-
Identification of the endothelial cell binding site for factor IX.Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11068-73. doi: 10.1073/pnas.93.20.11068. Proc Natl Acad Sci U S A. 1996. PMID: 8855310 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
