Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Aug:164:114938.
doi: 10.1016/j.biopha.2023.114938. Epub 2023 Jun 1.

Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer

Pratibha Pandey  1 , Fahad Khan  2 , Min Choi  3 , Sujeet Kumar Singh  1 , Han Na Kang  4 , Moon Nyeo Park  3 , Seong-Gyu Ko  5 , Sanjeev Kumar Sahu  6 , Rupa Mazumder  7 , Bonglee Kim  8
Affiliations
Free article
Review

Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer

Pratibha Pandey et al. Biomed Pharmacother. 2023 Aug.
Free article

Abstract

In the current period of drug development, natural products have provided an unrivaled supply of anticancer medications. By modifying the cancer microenvironment and various signaling pathways, natural products and their derivatives and analogs play a significant role in cancer treatment. These substances are effective against several signaling pathways, particularly the cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch, Wnt, and Hedgehog pathways). Natural products have a long history, but more research is needed to understand their current function in the research and development of cancer treatments and the potential for natural products to serve as a significant source of therapeutic agents in the future. Several target-specific anticancer medications failed to treat cancer, necessitating research into natural compounds with multiple target properties. To help develop a better treatment plan for managing breast cancer, this review has outlined the anticancerous potential of several therapeutic approaches targeting the notch signaling system in breast tumors.

Keywords: Breast cancer; Nanoparticles; Natural compounds; Notch signaling pathway; Targeted therapeutics.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Similar articles

See all similar articles

Cited by

LinkOut - more resources