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Review
. 2023 Jul:163:114861.
doi: 10.1016/j.biopha.2023.114861. Epub 2023 May 11.

Transient Receptor Potential Vanilloid (TRPV4) channel inhibition: A novel promising approach for the treatment of lung diseases

Mohit Kumar  1 , Md Kamaruz Zaman  2 , Sanghita Das  3 , Danswrang Goyary  4 , Manash Pratim Pathak  5 , Pronobesh Chattopadhyay  6
Affiliations
Free article
Review

Transient Receptor Potential Vanilloid (TRPV4) channel inhibition: A novel promising approach for the treatment of lung diseases

Mohit Kumar et al. Biomed Pharmacother. 2023 Jul.
Free article

Abstract

Research on transient receptor potential vanilloid-4 (TRPV4) can provide a promising potential therapeutic target in the development of novel medicines for lung disorders. TRPV4 expresses in lung tissue and plays an important role in the maintenance of respiratory homeostatic function. TRPV4 is upregulated in life-threatening respiratory diseases like pulmonary hypertension, asthma, cystic fibrosis, and chronic obstructive pulmonary diseases. TRPV4 is linked to several proteins that have physiological functions and are sensitive to a wide variety of stimuli, such as mechanical stimulation, changes in temperature, and hypotonicity, and responds to a variety of proteins and lipid mediators, including anandamide (AA), the arachidonic acid metabolite, 5,6-epoxyeicosatrienoic acid (5,6-EET), a plant dimeric diterpenoid called bisandrographolide A (BAA), and the phorbol ester 4-alpha-phorbol-12,13-didecanoate (4α-PDD). This study focused on relevant research evidence of TRPV4 in lung disorders and its agonist and antagonist effects. TRPV4 can be a possible target of discovered molecules that exerts high therapeutic potential in the treatment of respiratory diseases by inhibiting TRPV4.

Keywords: Agonist; Antagonist; Hypoxia; Lung diseases; TRPV4.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no competing interests.

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