Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series

doi:10.1016/j.ajpc.2023.100495

. 2023 Apr 6:14:100495.

doi: 10.1016/j.ajpc.2023.100495. eCollection 2023 Jun.

Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series

Tyler Schmidt¹, David M Harmon¹, Erica Kludtke¹, Alicia Mickow¹, Vinaya Simha², Stephen Kopecky¹

Affiliations

¹ Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, United States.
² Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN, United States.

PMID: 37096158
PMCID: PMC10121782
DOI: 10.1016/j.ajpc.2023.100495

Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series

Tyler Schmidt et al. Am J Prev Cardiol. 2023.

. 2023 Apr 6:14:100495.

doi: 10.1016/j.ajpc.2023.100495. eCollection 2023 Jun.

Authors

Tyler Schmidt¹, David M Harmon¹, Erica Kludtke¹, Alicia Mickow¹, Vinaya Simha², Stephen Kopecky¹

Affiliations

¹ Department of Cardiovascular Disease, Mayo Clinic, Rochester, MN, United States.
² Division of Endocrinology, Diabetes, and Metabolism, Mayo Clinic, Rochester, MN, United States.

PMID: 37096158
PMCID: PMC10121782
DOI: 10.1016/j.ajpc.2023.100495

Abstract

High-fat, low carb dieting, also known as the "ketogenic diet," has increased in popularity as a rapid weight-loss tool. Previous studies describe a modest elevation in cholesterol in the average keto-diet participant without specific cardiovascular impact. We hypothesize that patients with a genetic predisposition to cholesterol metabolism dysregulation may have a disproportionate elevation in cholesterol in response to ketogenic dieting.

Keywords: Genetic; Hypercholesterolemia; Hyperlipidemia; Ketogenic diet.

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Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig 1 — **Fig. 1**
Trend of LDL Cholesterol Levels on Keto Diet Patients.

Fig 2 — **Fig. 2**
Trend of LDL Cholesterol on Keto Diet Patients With and Without Statin Therapy.

Fig 3 — **Fig. 3**
Impact of Ketogenic Diet on LDL Cholesterol Levels based on BMI Levels.

See this image and copyright information in PMC

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[1] O'Neill B., Raggi P. The ketogenic diet: pros and cons. Atherosclerosis. 2020;292:119–126. - PubMed

[2] O'Neill B., Raggi P. The ketogenic diet: pros and cons. Atherosclerosis. 2020;292:119–126. - PubMed

[3] Bueno N.B., et al. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013;110(7):1178–1187. - PubMed

[4] Bueno N.B., et al. Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials. Br J Nutr. 2013;110(7):1178–1187. - PubMed

[5] Walczyk T., Wick J.Y. The ketogenic diet: making a comeback. Consult Pharm. 2017;32(7):388–396. - PubMed

[6] Walczyk T., Wick J.Y. The ketogenic diet: making a comeback. Consult Pharm. 2017;32(7):388–396. - PubMed

[7] Arnett D.K., et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of cardiology/american heart association task force on clinical practice guidelines. Circulation. 2019;140(11):e596–e646. - PMC - PubMed

[8] Arnett D.K., et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American college of cardiology/american heart association task force on clinical practice guidelines. Circulation. 2019;140(11):e596–e646. - PMC - PubMed

[9] Kirkpatrick C.F., et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. J Clin Lipidol. 2019;13(5):689–711. e1. - PubMed

[10] Kirkpatrick C.F., et al. Review of current evidence and clinical recommendations on the effects of low-carbohydrate and very-low-carbohydrate (including ketogenic) diets for the management of body weight and other cardiometabolic risk factors: a scientific statement from the National Lipid Association Nutrition and Lifestyle Task Force. J Clin Lipidol. 2019;13(5):689–711. e1. - PubMed

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Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series

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Dramatic elevation of LDL cholesterol from ketogenic-dieting: A Case Series

Authors

Affiliations

Abstract

Conflict of interest statement

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References

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Abstract

Conflict of interest statement

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