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Review
. 2023 May:161:114451.
doi: 10.1016/j.biopha.2023.114451. Epub 2023 Mar 2.

Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy

Lianlian Fan  1 , Anhui Wei  2 , Zihui Gao  3 , Xupeng Mu  4
Affiliations
Free article
Review

Current progress of mesenchymal stem cell membrane-camouflaged nanoparticles for targeted therapy

Lianlian Fan et al. Biomed Pharmacother. 2023 May.
Free article

Abstract

Nanodrug delivery systems have been widely used in disease treatment. However, weak drug targeting, easy to be cleared by the immune system, and low biocompatibility are great obstacles for drug delivery. As an important part of cell information transmission and behavior regulation, cell membrane can be used as drug coating material which represents a promising strategy and can overcome these limitations. Mesenchymal stem cell (MSC) membrane, as a new carrier, has the characteristics of active targeting and immune escape of MSC, and has broad application potential in tumor treatment, inflammatory disease, tissue regeneration and other fields. Here, we review recent progress on the use of MSC membrane-coated nanoparticles for therapy and drug delivery, aiming to provide guidance for the design and clinical application of membrane carrier in the future.

Keywords: Drug delivery systems; Mesenchymal stem cell; Nanotechnology.

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