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Review
. 2023 Mar 5:634:122632.
doi: 10.1016/j.ijpharm.2023.122632. Epub 2023 Jan 21.

Ether lipids from archaeas in nano-drug delivery and vaccination

Eder Lilia Romero  1 , Maria Jose Morilla  2
Affiliations
Review

Ether lipids from archaeas in nano-drug delivery and vaccination

Eder Lilia Romero et al. Int J Pharm. .

Abstract

Archaea are microorganisms more closely related to eukaryotes than bacteria. Almost 50 years after being defined as a new domain of life on earth, new species continue to be discovered and their phylogeny organized. The study of the relationship between their genetics and metabolism and some of their extreme habitats has even positioned them as a model of extraterrestrial life forms. Archaea, however, are deeply connected to the life of our planet: they can be found in arid, acidic, warm areas; on most of the earth's surface, which is cold (below 5 °C), playing a prominent role in the cycles of organic materials on a global scale and they are even part of our microbiota. The constituent materials of these microorganisms differ radically from those produced by eukaryotes and bacteria, and the nanoparticles that can be manufactured using their ether lipids as building blocks exhibit unique properties that are of interest in nanomedicine. Here, we present for the first time a complete overview of the pre-clinical applications of nanomedicines based on ether archaea lipids, focused on drug delivery and adjuvancy over the last 25 years, along with a discussion on their pros, cons and their future industrial implementation.

Keywords: Adjuvants; Archaeosomes; Drug delivery.

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Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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