Metabolic Messengers: glucagon

doi:10.1038/s42255-022-00725-3

Review

. 2023 Feb;5(2):186-192.

doi: 10.1038/s42255-022-00725-3. Epub 2023 Jan 13.

Metabolic Messengers: glucagon

Patrick E MacDonald^{1

2}, Patrik Rorsman^{3

4}

Affiliations

¹ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
² Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
³ Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. patrik.rorsman@drl.ox.ac.uk.
⁴ Metabolic Physiology, Institute of Neuroscience and Physiology, University of Göteborg, Gothenburg, Sweden. patrik.rorsman@drl.ox.ac.uk.

PMID: 36639733
DOI: 10.1038/s42255-022-00725-3

Review

Metabolic Messengers: glucagon

Patrick E MacDonald et al. Nat Metab. 2023 Feb.

. 2023 Feb;5(2):186-192.

doi: 10.1038/s42255-022-00725-3. Epub 2023 Jan 13.

Authors

Patrick E MacDonald^{1

2}, Patrik Rorsman^{3

4}

Affiliations

¹ Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada.
² Department of Pharmacology, University of Alberta, Edmonton, AB, Canada.
³ Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. patrik.rorsman@drl.ox.ac.uk.
⁴ Metabolic Physiology, Institute of Neuroscience and Physiology, University of Göteborg, Gothenburg, Sweden. patrik.rorsman@drl.ox.ac.uk.

PMID: 36639733
DOI: 10.1038/s42255-022-00725-3

Abstract

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and secrete glucagon-one of the body's few blood glucose-increasing hormones. Diabetes is a bihormonal disorder, resulting from both inadequate insulin secretion and dysregulation of glucagon. The year 2023 marks the 100th anniversary of the discovery of glucagon, making it particularly timely to highlight the roles of this systemic metabolic messenger in health and disease.

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References

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[1] Cryer, P. E. Comprehensiv. Physiol. https://doi.org/10.1002/cphy.cp070235 (2011). - DOI

[2] Cryer, P. E. Comprehensiv. Physiol. https://doi.org/10.1002/cphy.cp070235 (2011). - DOI

[3] Frayn, K. & Evans, R. Human Metabolism: A Regulatory Perspective 4th edn (Wiley Blackwell, 2019).

[4] Frayn, K. & Evans, R. Human Metabolism: A Regulatory Perspective 4th edn (Wiley Blackwell, 2019).

[5] Gromada, J., Franklin, I. & Wollheim, C. B. Endocr. Rev. 28, 84–116 (2007). - PubMed - DOI

[6] Gromada, J., Franklin, I. & Wollheim, C. B. Endocr. Rev. 28, 84–116 (2007). - PubMed - DOI

[7] Müller, T. D. et al. Physiol. Rev. 97, 721–766 (2017). - PubMed - DOI

[8] Müller, T. D. et al. Physiol. Rev. 97, 721–766 (2017). - PubMed - DOI

[9] Andersen, D. B. & Holst, J. J. Peptides 148, 170683 (2021). - PubMed - DOI

[10] Andersen, D. B. & Holst, J. J. Peptides 148, 170683 (2021). - PubMed - DOI

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Metabolic Messengers: glucagon

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Metabolic Messengers: glucagon

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