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Review
. 2022 Oct 21;8(1):121-128.
doi: 10.3233/BPL-220140. eCollection 2022.

Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling

Marc Fakhoury  1 , Fady Eid  1 , Perla El Ahmad  1 , Reine Khoury  1 , Amar Mezher  1 , Diala El Masri  1 , Zena Haddad  1 , Yara Zoghbi  1 , Litsa Maria Ghayad  1 , Sama F Sleiman  1 , Joseph S Stephan  2
Affiliations
Review

Exercise and Dietary Factors Mediate Neural Plasticity Through Modulation of BDNF Signaling

Marc Fakhoury et al. Brain Plast. .

Abstract

The term "neural plasticity" was first used to describe non-pathological changes in neuronal structure. Today, it is generally accepted that the brain is a dynamic system whose morphology and function is influenced by a variety of factors including stress, diet, and exercise. Neural plasticity involves learning and memory, the synthesis of new neurons, the repair of damaged connections, and several other compensatory mechanisms. It is altered in neurodegenerative disorders and following damage to the central or peripheral nervous system. Understanding the mechanisms that regulate neural plasticity in both healthy and diseased states is of significant importance to promote cognition and develop rehabilitation techniques for functional recovery after injury. In this minireview, we will discuss the mechanisms by which environmental factors promote neural plasticity with a focus on exercise- and diet-induced factors. We will highlight the known circulatory factors that are released in response to exercise and discuss how all factors activate pathways that converge in part on the activation of BDNF signaling. We propose to harness the therapeutic potential of exercise by using BDNF as a biomarker to identify novel endogenous factors that promote neural plasticity. We also discuss the importance of combining exercise factors with dietary factors to develop a lifestyle pill for patients afflicted by CNS disorders.

Keywords: BDNF; beta-hydroxybutyrate; diet; exercise; irisin; lactate; neural plasticity; osteocalcin.

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Conflict of interest statement

The authors have no conflict of interest to report.

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References

    1. Puderbaugh M, Emmady PD, Neuroplasticity. StatPearls. Treasure Island (FL). 2021. - PubMed
    1. Winner B, Winkler J, Adult neurogenesis in neurodegenerative diseases, Cold Spring Harb Perspect Biol 2015;7(4):a021287. - PMC - PubMed
    1. Price RB, Duman R, Neuroplasticity in cognitive and psychological mechanisms of depression: an integrative model, Mol Psychiatry 2020;25(3):530–43. - PMC - PubMed
    1. Li X, Hu L, The Role of Stress Regulation on Neural Plasticity in Pain Chronification, Neural Plast 2016;20166402942. - PMC - PubMed
    1. El Hayek L, Khalifeh M, Zibara V, Abi Assaad R, Emmanuel N, Karnib N, et al.., Lactate Mediates the Effects of Exercise on Learning and Memory through SIRT1-Dependent Activation of Hippocampal Brain-Derived Neurotrophic Factor (BDNF), J Neurosci 2019;39(13):2369–82. - PMC - PubMed

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