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Review
. 2022 Nov 25;378(6622):864-868.
doi: 10.1126/science.add9666. Epub 2022 Nov 24.

Scaling up complexity in synthetic developmental biology

Guillermo Martínez-Ara  1 , Kristina S Stapornwongkul  1 , Miki Ebisuya  1
Affiliations
Review

Scaling up complexity in synthetic developmental biology

Guillermo Martínez-Ara et al. Science. .

Abstract

The application of synthetic biology approaches to study development opens the possibility to build and manipulate developmental processes to understand them better. Researchers have reconstituted fundamental developmental processes, such as cell patterning and sorting, by engineering gene circuits in vitro. Moreover, new tools have been created that allow for the control of developmental processes in more complex organoids and embryos. Synthetic approaches allow testing of which components are sufficient to reproduce a developmental process and under which conditions as well as what effect perturbations have on other processes. We envision that the future of synthetic developmental biology requires an increase in the diversity of available tools and further efforts to combine multiple developmental processes into one system.

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