doi: 10.1016/0006-291x(87)90969-7.
Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex
- PMID: 3632687
- DOI: 10.1016/0006-291x(87)90969-7
Item in Clipboard
Protective effect of endogenous coenzyme Q on both lipid peroxidation and respiratory chain inactivation induced by an adriamycin-iron complex
Biochem Biophys Res Commun.
.
Abstract
Mitochondria from beef heart have been partially depleted of coenzyme Q by pentane extraction. It has been found that lipid peroxidation induced by an adriamycin-iron complex proceeds at a higher rate in this preparation than in coenzyme Q reincorporated mitochondria. Moreover in coenzyme Q depleted mitochondria both NADH and succinate oxidase activities result more affected. These observations indicate that endogenous coenzyme Q can effectively protect mitochondria from membrane lipid oxidative damage induced by adriamycin-iron and can reduce the inactivation of NADH and succinate oxidases.
Similar articles
-
Pro- and anti-oxidant activities of the mitochondrial respiratory chain: factors influencing NAD(P)H-induced lipid peroxidation.Biochim Biophys Acta. 1997 Jan 16;1318(1-2):246-54. doi: 10.1016/s0005-2728(96)00142-9. Biochim Biophys Acta. 1997. PMID: 9030267
-
Destruction of phospholipids and respiratory-chain activity in pig-heart submitochondrial particles induced by an adriamycin-iron complex.Eur J Biochem. 1983 May 16;132(3):551-6. doi: 10.1111/j.1432-1033.1983.tb07397.x. Eur J Biochem. 1983. PMID: 6852013
-
Coenzyme Q deficiency in mitochondria: kinetic saturation versus physical saturation.Mol Aspects Med. 1997;18 Suppl:S25-31. doi: 10.1016/s0098-2997(97)00029-0. Mol Aspects Med. 1997. PMID: 9266503 Review.
-
NADH- and NADPH-dependent lipid peroxidation in bovine heart submitochondrial particles. Dependence on the rate of electron flow in the respiratory chain and an antioxidant role of ubiquinol.Biochem J. 1980 Dec 15;192(3):853-60. doi: 10.1042/bj1920853. Biochem J. 1980. PMID: 7236242 Free PMC article.
-
An updating of the biochemical function of coenzyme Q in mitochondria.Mol Aspects Med. 1994;15 Suppl:s29-36. doi: 10.1016/0098-2997(94)90010-8. Mol Aspects Med. 1994. PMID: 7752842 Review.
Cited by
-
Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.J Anat. 1993 Dec;183 ( Pt 3)(Pt 3):451-61. J Anat. 1993. PMID: 8300427 Free PMC article.
-
Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene.Commun Biol. 2023 Nov 1;6(1):1108. doi: 10.1038/s42003-023-05477-8. Commun Biol. 2023. PMID: 37914914 Free PMC article.
-
Lovastatin decreases coenzyme Q levels in rats.Proc Natl Acad Sci U S A. 1990 Nov;87(22):8928-30. doi: 10.1073/pnas.87.22.8928. Proc Natl Acad Sci U S A. 1990. PMID: 2247467 Free PMC article.
-
Hypoxia and IF₁ Expression Promote ROS Decrease in Cancer Cells.Cells. 2018 Jun 21;7(7):64. doi: 10.3390/cells7070064. Cells. 2018. PMID: 29933600 Free PMC article.
-
Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency.Biochem J. 2001 Aug 1;357(Pt 3):887-92. doi: 10.1042/0264-6021:3570887. Biochem J. 2001. PMID: 11463362 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
