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Review
. 2022:113:25-88.
doi: 10.1016/bs.aivir.2022.07.001. Epub 2022 Aug 22.

Animal models of alphavirus infection and human disease

Cormac J Lucas  1 , Thomas E Morrison  2
Affiliations
Review

Animal models of alphavirus infection and human disease

Cormac J Lucas et al. Adv Virus Res. 2022.

Abstract

Alphaviruses are a large group (>30 species) of enveloped, positive-strand RNA viruses. The re-emergence of mosquito-transmitted alphaviruses associated with human diseases ranging from severe and potentially fatal neurological disease to chronic arthritic disease highlights the need to understand the biology and pathogenesis of alphaviruses. Here, we review the development and use of animal models of alphavirus transmission and human disease, and discuss areas for continued refinement of these models including possible avenues for future investigation.

Keywords: Alphavirus; Animal model; Arthritogenic; Encephalitic; Pathogenesis.

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