doi: 10.1126/science.3629259.
Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system
- PMID: 3629259
- DOI: 10.1126/science.3629259
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Identification of a novel thyroid hormone receptor expressed in the mammalian central nervous system
Science.
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Abstract
A complementary DNA clone derived from rat brain messenger RNA has been isolated on the basis of homology to the human thyroid hormone receptor gene. Expression of this complementary DNA produces a high-affinity binding protein for thyroid hormones. Sequence analysis and the mapping of this gene to a distinct human genetic locus indicate the existence of multiple human thyroid hormone receptors. Messenger RNA from this gene is expressed in a tissue-specific fashion with highest levels in the central nervous system.
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