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. 2022 Dec:65:100885.
doi: 10.1016/j.drup.2022.100885. Epub 2022 Oct 20.

Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Paul E Verweij  1 , Maiken C Arendrup  2 , Ana Alastruey-Izquierdo  3 , Jeremy A W Gold  4 , Shawn R Lockhart  4 , Tom Chiller  4 , P Lewis White  5
Affiliations

Dual use of antifungals in medicine and agriculture: How do we help prevent resistance developing in human pathogens?

Paul E Verweij et al. Drug Resist Updat. 2022 Dec.

Abstract

Azole resistance in Aspergillus fumigatus is a One Health resistance threat, where azole fungicide exposure compromises the efficacy of medical azoles. The use of the recently authorized fungicide ipflufenoquin, which shares its mode-of-action with a new antifungal olorofim, underscores the need for risk assessment for dual use of antifungals.

Keywords: Aspergillus fumigatus; DHODH inhibitor; One Health; olorofim; triazole resistance.

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Conflict of interest statement

Declaration of Competing Interest Paul E Verweij declares grants from F2G and Gilead Sciences and payments for lectures and advisory boards by F2G, Gilead Sciences, Pfizer and Mundipharma. All payments to institute. Maiken C Arendrup, Ana Alastruey-Izquierdo, Jeremy A W Gold, Shawn R Lockhart, and Tom Chiller declare no competing interests. P Lewis White declares grants from F2G, CERBA, IHMA, payments for lectures and advisory boards by F2G, Gilead Sciences, and Pfizer, and support for travel from OLM.

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