International expert consensus on immunotherapy for early-stage non-small cell lung cancer

doi:10.21037/tlcr-22-617

Review

. 2022 Sep;11(9):1742-1762.

doi: 10.21037/tlcr-22-617.

International expert consensus on immunotherapy for early-stage non-small cell lung cancer

Wenhua Liang¹, Kaican Cai², Qingdong Cao³, Chun Chen⁴, Haiquan Chen⁵, Jun Chen⁶, Ke-Neng Chen⁷, Qixun Chen^{8

9}, Tianqing Chu¹⁰, Yuchao Dong¹¹, Jiang Fan^{12

13}, Wentao Fang¹⁴, Junke Fu¹⁵, Xiangning Fu¹⁶, Shugeng Gao¹⁷, Di Ge¹⁸, Guojun Geng¹⁹, Qing Geng²⁰, Jie He¹⁷, Jian Hu²¹, Jie Hu²², Wei-Dong Hu²³, Feng Jiang²⁴, Tao Jiang²⁵, Wenjie Jiao²⁶, He-Cheng Li²⁷, Qiang Li²⁸, Shanqing Li²⁹, Shuben Li¹, Xiangnan Li³⁰, Yong-De Liao³¹, Changhong Liu³², Hongxu Liu³³, Yang Liu, Zhuming Lu, Qingquan Luo³⁴, Haitao Ma³⁵, Xiaojie Pan³⁶, Guibin Qiao³⁷, Shengxiang Ren³⁸, Weiyu Shen³⁹, Yong Song⁴⁰, Daqiang Sun⁴¹, Guangsuo Wang⁴², Jie Wang⁴³, Mengzhao Wang⁴⁴, Qiwen Wang⁴⁵, Wen-Xiang Wang⁴⁶, Li Wei⁴⁷, Ming Wu⁴⁸, Nan Wu⁴⁹, Hui Xia⁵⁰, Shi-Dong Xu⁵¹, Fan Yang⁵², Kang Yang⁵³, Yue Yang⁵⁴, Fenglei Yu⁵⁵, Zhen-Tao Yu⁵⁶, Dong-Sheng Yue⁵⁷, Lanjun Zhang⁵⁸, Weidong Zhang⁵⁹, Zhenfa Zhang⁶⁰, Guofang Zhao⁶¹, Jian Zhao⁶², Xiaojing Zhao⁶³, Chengzhi Zhou⁶⁴, Qinghua Zhou⁶⁵, Kunshou Zhu⁶⁶, Yuming Zhu⁶⁷, Toyoaki Hida⁶⁸, Wolfram C M Dempke⁶⁹, Antonio Rossi⁷⁰, Marc de Perrot⁷¹, Robert A Ramirez⁷², Mariano Provencio⁷³, Jay M Lee⁷⁴, Antonio Passaro⁷⁵, Lorenzo Spaggiari^{76

77}, Jonathan Spicer⁷⁸, Nicolas Girard⁷⁹, Patrick M Forde⁸⁰, Tony S K Mok⁸¹, Tina Cascone⁸², Jianxing He¹

Affiliations

¹ Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
² Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
³ Department of Thoracic Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
⁴ Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
⁵ Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
⁶ Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
⁷ Department of Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
⁸ Department of Thoracic Surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
⁹ Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Science, Hangzhou, China.
¹⁰ Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹¹ Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, China.
¹² Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
¹³ Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
¹⁴ Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
¹⁵ Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
¹⁶ Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹⁷ Thoracic Surgery Department, National Cancer Center-National Clinical Research Center for Cancer-Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁸ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
¹⁹ Department of Thoracic Surgery, Xiamen Key Laboratory of Thoracic Tumor Diagnosis and Treatment, Institute of Lung Cancer, The First Affiliated Hospital of Xiamen University, School of Clinical Medicine, Fujian Medical University, Xiamen, China.
²⁰ Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
²¹ Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
²² Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
²³ Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
²⁴ Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
²⁵ Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.
²⁶ Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
²⁷ Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
²⁸ Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
²⁹ Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³⁰ Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³¹ Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³² Department of Thoracic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
³³ Department of Thoracic Surgery, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, China.
³⁴ Department of Thoracic Surgery, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
³⁵ Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
³⁶ Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou China.
³⁷ Division of Thoracic Surgery, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, The Second School of Clinical Medicine, Southern Medical University, Shantou University Medical College, Guangzhou, China.
³⁸ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
³⁹ Department of Thoracic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.
⁴⁰ Department of Respiratory Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China.
⁴¹ Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin, China.
⁴² Department of Thoracic Surgery, The First Affiliated Hospital of Southern, University of Sciences and Technology, Shenzhen People's Hospital, Shenzhen, China.
⁴³ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴⁴ Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
⁴⁵ Department of Thoracic Oncosurgery, Jilin Province Tumor Hospital, Changchun, China.
⁴⁶ Department of Thoracic Surgery II, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
⁴⁷ Department of Thoracic Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
⁴⁸ Department of Thoracic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁴⁹ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China.
⁵⁰ Department of Cardiothoracic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
⁵¹ Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
⁵² Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
⁵³ Department of Thoracic Surgery, GuiQian International General Hospital, Guiyang, China.
⁵⁴ Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China.
⁵⁵ Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
⁵⁶ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
⁵⁷ Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
⁵⁸ Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁵⁹ Department of Thoracic Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
⁶⁰ Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
⁶¹ Department of Thoracic Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁶² Department of Thoracic Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.
⁶³ Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
⁶⁵ Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, China.
⁶⁶ Department of Thoracic Surgery, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.
⁶⁷ Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
⁶⁸ Lung Cancer Center, Central Japan International Medical Center, Minokamo, Japan.
⁶⁹ Department of Hematology and Oncology, University Medical School, Munich, Germany.
⁷⁰ Oncology Center of Excellence, Therapeutic Science & Strategy Unit, IQVIA, Milan, Italy.
⁷¹ Division of Thoracic Surgery, Toronto General Hospital and Princess Margaret Cancer Centre, Toronto, ON, Canada.
⁷² Department of Internal Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁷³ Service of Medical Oncology, Puerta del Hierro University Hospital of Madrid, Madrid, Spain.
⁷⁴ Division of Thoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁷⁵ Division of Medical Oncology, European Institute of Oncology IRCCS, Milan, Italy.
⁷⁶ Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
⁷⁷ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
⁷⁸ Division of Thoracic Surgery, Department of Surgery, McGill University Health Centre, Montreal, QC, Canada.
⁷⁹ Thoracic Oncology Service, Thorax Institute Curie Montsouris, Institut Curie, Paris, France.
⁸⁰ Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
⁸¹ Department of Clinical Oncology, State Key Laboratory of South China, Chinese University of Hong Kong, Shatin, Hong Kong, China.
⁸² Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 36248334
PMCID: PMC9554679
DOI: 10.21037/tlcr-22-617

Review

International expert consensus on immunotherapy for early-stage non-small cell lung cancer

Wenhua Liang et al. Transl Lung Cancer Res. 2022 Sep.

. 2022 Sep;11(9):1742-1762.

doi: 10.21037/tlcr-22-617.

Authors

Affiliations

¹ Department of Thoracic Surgery and Oncology, The First Affiliated Hospital of Guangzhou Medical University, National Center for Respiratory Medicine, State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, Guangzhou, China.
² Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
³ Department of Thoracic Surgery, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China.
⁴ Department of Thoracic Surgery, Fujian Medical University Union Hospital, Fuzhou, China.
⁵ Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China.
⁶ Department of Lung Cancer Surgery, Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.
⁷ Department of Thoracic Surgery, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, China.
⁸ Department of Thoracic Surgery, Cancer Hospital of University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China.
⁹ Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Science, Hangzhou, China.
¹⁰ Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
¹¹ Department of Respiratory and Critical Care Medicine, Shanghai Changhai Hospital, The First Affiliated Hospital of Second Military Medical University, Shanghai, China.
¹² Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
¹³ Department of Thoracic Surgery, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China.
¹⁴ Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
¹⁵ Department of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
¹⁶ Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
¹⁷ Thoracic Surgery Department, National Cancer Center-National Clinical Research Center for Cancer-Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
¹⁸ Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
¹⁹ Department of Thoracic Surgery, Xiamen Key Laboratory of Thoracic Tumor Diagnosis and Treatment, Institute of Lung Cancer, The First Affiliated Hospital of Xiamen University, School of Clinical Medicine, Fujian Medical University, Xiamen, China.
²⁰ Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China.
²¹ Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
²² Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
²³ Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China.
²⁴ Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, China.
²⁵ Department of Thoracic Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, China.
²⁶ Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
²⁷ Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
²⁸ Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
²⁹ Department of Thoracic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
³⁰ Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
³¹ Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
³² Department of Thoracic Surgery, The Second Hospital of Dalian Medical University, Dalian, China.
³³ Department of Thoracic Surgery, Cancer Hospital of China Medical University, Cancer Hospital of Dalian University of Technology, Liaoning Cancer Hospital & Institute, Shenyang, China.
³⁴ Department of Thoracic Surgery, Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China.
³⁵ Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
³⁶ Department of Thoracic Surgery, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou China.
³⁷ Division of Thoracic Surgery, Guangdong Provincial People's Hospital & Guangdong Academy of Medical Sciences, The Second School of Clinical Medicine, Southern Medical University, Shantou University Medical College, Guangzhou, China.
³⁸ Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
³⁹ Department of Thoracic Surgery, Ningbo Medical Center Lihuili Hospital, Ningbo University, Ningbo, China.
⁴⁰ Department of Respiratory Medicine, Jinling Hospital, Nanjing Medical University, Nanjing, China.
⁴¹ Department of Thoracic Surgery, Tianjin Chest Hospital, Tianjin, China.
⁴² Department of Thoracic Surgery, The First Affiliated Hospital of Southern, University of Sciences and Technology, Shenzhen People's Hospital, Shenzhen, China.
⁴³ Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴⁴ Department of Respiratory and Critical Care Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
⁴⁵ Department of Thoracic Oncosurgery, Jilin Province Tumor Hospital, Changchun, China.
⁴⁶ Department of Thoracic Surgery II, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University/Hunan Cancer Hospital, Changsha, China.
⁴⁷ Department of Thoracic Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, China.
⁴⁸ Department of Thoracic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁴⁹ Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Thoracic Surgery II, Peking University Cancer Hospital & Institute, Beijing, China.
⁵⁰ Department of Cardiothoracic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, China.
⁵¹ Department of Thoracic Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
⁵² Department of Thoracic Surgery, Peking University People's Hospital, Beijing, China.
⁵³ Department of Thoracic Surgery, GuiQian International General Hospital, Guiyang, China.
⁵⁴ Department of Thoracic Surgery II, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Peking University Cancer Hospital and Institute, Beijing, China.
⁵⁵ Department of Thoracic Surgery, The Second Xiangya Hospital of Central South University, Changsha, China.
⁵⁶ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
⁵⁷ Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.
⁵⁸ Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, Guangzhou, China.
⁵⁹ Department of Thoracic Surgery, Tianjin First Central Hospital, School of Medicine, Nankai University, Tianjin, China.
⁶⁰ Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
⁶¹ Department of Thoracic Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China.
⁶² Department of Thoracic Surgery, Affiliated Cancer Hospital and Institute of Guangzhou Medical University, Guangzhou, China.
⁶³ Department of Thoracic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
⁶⁴ State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
⁶⁵ Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, China.
⁶⁶ Department of Thoracic Surgery, Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, Fuzhou, China.
⁶⁷ Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.
⁶⁸ Lung Cancer Center, Central Japan International Medical Center, Minokamo, Japan.
⁶⁹ Department of Hematology and Oncology, University Medical School, Munich, Germany.
⁷⁰ Oncology Center of Excellence, Therapeutic Science & Strategy Unit, IQVIA, Milan, Italy.
⁷¹ Division of Thoracic Surgery, Toronto General Hospital and Princess Margaret Cancer Centre, Toronto, ON, Canada.
⁷² Department of Internal Medicine, Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA.
⁷³ Service of Medical Oncology, Puerta del Hierro University Hospital of Madrid, Madrid, Spain.
⁷⁴ Division of Thoracic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
⁷⁵ Division of Medical Oncology, European Institute of Oncology IRCCS, Milan, Italy.
⁷⁶ Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
⁷⁷ Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy.
⁷⁸ Division of Thoracic Surgery, Department of Surgery, McGill University Health Centre, Montreal, QC, Canada.
⁷⁹ Thoracic Oncology Service, Thorax Institute Curie Montsouris, Institut Curie, Paris, France.
⁸⁰ Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA.
⁸¹ Department of Clinical Oncology, State Key Laboratory of South China, Chinese University of Hong Kong, Shatin, Hong Kong, China.
⁸² Department of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

PMID: 36248334
PMCID: PMC9554679
DOI: 10.21037/tlcr-22-617

No abstract available

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Conflict of interest statement

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tlcr.amegroups.com/article/view/10.21037/tlcr-22-617/coif). TH serves as an unpaid editorial board member of Translational Lung Cancer Research from January 2022 to December 2023. AR serves as an unpaid editorial board member of Translational Lung Cancer Research from November 2020 to October 2022. RAR serves as an unpaid editorial board member of Translational Lung Cancer Research from January 2022 to December 2023. MP serves as an unpaid editorial board member of Translational Lung Cancer Research from October 2021 to September 2023. RAR has been a consultant for Amgen, Ipsen Biopharmaceuticals, Novartis, Advanced Accelerator Applications, Curium Pharma, EMD Serono, Astra-Zeneca. He has also received research funding (to institution) from Merck & Co and Aadi Biosciences. He is also on the speaker bureaus for Ipsen Biopharmaceuticals and Astra-Zeneca. Mariano Provencio received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing or educational events and consulting fees from BMS, Astra Zéneca, MSD, Roche, Takeda and Pfizer. Jay M. Lee reports advisory board/consultant of Astrazeneca, Bristol Myers Squibb, Genentech, Novartis, Roche; research support from Genentech, Novartis; steering committee of Genentech, Novartis; speaker’s bureau of AstraZeneca, Genentech, Roche; stock from Moderna; patents of UCLA. Antonio Passaro received honoraria for consulting, advisory role or lectures from AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Jansenn, Merck Sharp & Dohme, Roche Genentech, Novartis, MundiPharma, Daiichi Sankyo, eCancer and Medscape. TC reports speaker fees/honoraria from The Society for Immunotherapy of Cancer, Bristol Myers Squibb, Roche, Medscape, and PeerView; travel, food and beverage expenses from Dava Oncology; advisory role/consulting fees from AstraZeneca, Bristol Myers Squibb, EMD Serono, Merck & Co., Genentech, and Arrowhead Pharmaceuticals; and institutional research funding from AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim and EMD Serono. The other authors have no conflicts of interest to declare.

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References

1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660 - DOI - PubMed
1. Cao W, Chen HD, Yu YW, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 2021;134:783-91. 10.1097/CM9.0000000000001474 - DOI - PMC - PubMed
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1. Reck M, Rabe KF. Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer. N Engl J Med 2017;377:849-61. 10.1056/NEJMra1703413 - DOI - PubMed
1. Uramoto H, Tanaka F. Recurrence after surgery in patients with NSCLC. Transl Lung Cancer Res 2014;3:242-9. - PMC - PubMed

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[1] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660 - DOI - PubMed

[2] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71:209-49. 10.3322/caac.21660 - DOI - PubMed

[3] Cao W, Chen HD, Yu YW, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 2021;134:783-91. 10.1097/CM9.0000000000001474 - DOI - PMC - PubMed

[4] Cao W, Chen HD, Yu YW, et al. Changing profiles of cancer burden worldwide and in China: a secondary analysis of the global cancer statistics 2020. Chin Med J (Engl) 2021;134:783-91. 10.1097/CM9.0000000000001474 - DOI - PMC - PubMed

[5] Zheng RS, Sun KX, Zhang SW, et al. Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi 2019;41:19-28. - PubMed

[6] Zheng RS, Sun KX, Zhang SW, et al. Report of cancer epidemiology in China, 2015. Zhonghua Zhong Liu Za Zhi 2019;41:19-28. - PubMed

[7] Reck M, Rabe KF. Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer. N Engl J Med 2017;377:849-61. 10.1056/NEJMra1703413 - DOI - PubMed

[8] Reck M, Rabe KF. Precision Diagnosis and Treatment for Advanced Non-Small-Cell Lung Cancer. N Engl J Med 2017;377:849-61. 10.1056/NEJMra1703413 - DOI - PubMed

[9] Uramoto H, Tanaka F. Recurrence after surgery in patients with NSCLC. Transl Lung Cancer Res 2014;3:242-9. - PMC - PubMed

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International expert consensus on immunotherapy for early-stage non-small cell lung cancer

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International expert consensus on immunotherapy for early-stage non-small cell lung cancer

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