Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

doi:10.1016/j.ejmech.2022.114606

Review

. 2022 Oct 5:240:114606.

doi: 10.1016/j.ejmech.2022.114606. Epub 2022 Jul 16.

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

Honghua Zhang¹, Yuying Wang², Yuqing Wang¹, Xuelin Li³, Shuzhi Wang⁴, Zhen Wang⁵

Affiliations

¹ School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
² State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
³ School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: liduan19@163.com.
⁴ School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: shu-zhi.wang@usc.edu.cn.
⁵ The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: zhenw@lzu.edu.cn.

PMID: 35858523
DOI: 10.1016/j.ejmech.2022.114606

Review

Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

Honghua Zhang et al. Eur J Med Chem. 2022.

. 2022 Oct 5:240:114606.

doi: 10.1016/j.ejmech.2022.114606. Epub 2022 Jul 16.

Authors

Honghua Zhang¹, Yuying Wang², Yuqing Wang¹, Xuelin Li³, Shuzhi Wang⁴, Zhen Wang⁵

Affiliations

¹ School of Pharmacy, Lanzhou University, Lanzhou, 730000, China.
² State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China.
³ School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: liduan19@163.com.
⁴ School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: shu-zhi.wang@usc.edu.cn.
⁵ The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China; School of Pharmaceutical Science, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, China. Electronic address: zhenw@lzu.edu.cn.

PMID: 35858523
DOI: 10.1016/j.ejmech.2022.114606

Abstract

Alzheimer's disease (AD), as the fourth leading cause of death among the elderly worldwide, has brought enormous challenge to the society. Due to its extremely complex pathogeneses, the development of multi-target directed ligands (MTDLs) becomes the major strategy for combating AD. Carbamate moiety, as an essential building block in the development of MTDLs, exhibits structural similarity to neurotransmitter acetylcholine (ACh) and has piqued extensive attention in discovering multifunctional cholinesterase inhibitors. To date, numerous preclinical studies demonstrate that carbamate-based cholinesterase inhibitors can prominently increase the level of ACh and improve cognition impairments and behavioral deficits, providing a privileged strategy for the treatment of AD. Based on the recent research focus on the novel cholinesterase inhibitors with multiple biofunctions, this review aims at summarizing and discussing the most recent studies excavating the potential carbamate-based MTDLs with cholinesterase inhibition efficacy, to accelerate the pace of pleiotropic cholinesterase inhibitors for coping AD.

Keywords: Alzheimer's disease; Carbamate-based MTDLs; Cholinesterase inhibitors.

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Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

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Recent advance on carbamate-based cholinesterase inhibitors as potential multifunctional agents against Alzheimer's disease

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