Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications

doi:10.1097/CM9.0000000000001857

. 2022 Aug 5;135(15):1803-1805.

doi: 10.1097/CM9.0000000000001857.

Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications

Na Liu^{1

2}, Yun Xie³, Yonghuan Zhen¹, Yujia Shang^{1

2}, GuanhuiEr Wang¹, Lingjuan Zhu², Yang An¹

Affiliations

¹ Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China.
² College of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
³ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

PMID: 35633586
PMCID: PMC9521765
DOI: 10.1097/CM9.0000000000001857

Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications

Na Liu et al. Chin Med J (Engl). 2022.

. 2022 Aug 5;135(15):1803-1805.

doi: 10.1097/CM9.0000000000001857.

Authors

Na Liu^{1

2}, Yun Xie³, Yonghuan Zhen¹, Yujia Shang^{1

2}, GuanhuiEr Wang¹, Lingjuan Zhu², Yang An¹

Affiliations

¹ Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China.
² College of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China.
³ Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.

PMID: 35633586
PMCID: PMC9521765
DOI: 10.1097/CM9.0000000000001857

No abstract available

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Conflict of interest statement

None.

Figures

**Figure 1**
Signaling pathway diagram of ADSC-Exos promoting wound healing. A: TGF-β signaling pathway; B: ERK/MAPK signaling pathway; C: PI3K/Akt signaling pathway; D: Wnt/β-catenin signaling pathway; E: JAK-STAT signaling pathway. ADSC-Exos: exosomes derived from adipose stem cell; TGFβ: transforming growth factor beta; ERK: extracellular regulated protein kinases; MAPK: mitogen-activated protein kinases; PI3K: phosphatidylinositol 3-kinases; JAK: Janus kinase; STAT: signal transducer and activator of transcription; SARA: subacute ruminal acidosis; GRB: Growth factor receptor-bound protein; SOS: son of sevenless factor.

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References

1. Hoang DH, Nguyen TD, Nguyen HP, Nguyen XH, Do PTX, Dang VD, et al. . Differential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue and umbilical cord under serum- and xeno-free condition. Front Mol Biosci 2020; 7:119.doi: 10.3389/fmolb.2020.00119. - PMC - PubMed
1. Li X, Xie X, Lian W, Shi R, Han S, Zhang H, et al. . Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 2018; 50:1–14. doi: 10.1038/s12276-018-0058-5. - PMC - PubMed
1. Yang Y, Cai Y, Zhang Y, Liu J, Xu Z. Exosomes secreted by adipose-derived stem cells contribute to angiogenesis of brain microvascular endothelial cells following oxygen-glucose deprivation in vitro through microRNA-181b/TRPM7 axis. J Mol Neurosci 2018; 65:74–83. doi: 10.1007/s12031-018-1071-9. - PubMed
1. An Y, Zhao J, Nie F, Qin Z, Xue H, Wang G, et al. . Exosomes from Adipose-Derived Stem Cells (ADSCs) overexpressing miR-21 promote vascularization of endothelial cells. Sci Rep 2019; 9:12861.doi: 10.1038/s41598-019-49339-y. - PMC - PubMed
1. Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M, Camussi G. Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun Signal 2014; 12:26.doi: 10.1186/1478-811X-12-26. - PMC - PubMed

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[1] Hoang DH, Nguyen TD, Nguyen HP, Nguyen XH, Do PTX, Dang VD, et al. . Differential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue and umbilical cord under serum- and xeno-free condition. Front Mol Biosci 2020; 7:119.doi: 10.3389/fmolb.2020.00119. - PMC - PubMed

[2] Hoang DH, Nguyen TD, Nguyen HP, Nguyen XH, Do PTX, Dang VD, et al. . Differential wound healing capacity of mesenchymal stem cell-derived exosomes originated from bone marrow, adipose tissue and umbilical cord under serum- and xeno-free condition. Front Mol Biosci 2020; 7:119.doi: 10.3389/fmolb.2020.00119. - PMC - PubMed

[3] Li X, Xie X, Lian W, Shi R, Han S, Zhang H, et al. . Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 2018; 50:1–14. doi: 10.1038/s12276-018-0058-5. - PMC - PubMed

[4] Li X, Xie X, Lian W, Shi R, Han S, Zhang H, et al. . Exosomes from adipose-derived stem cells overexpressing Nrf2 accelerate cutaneous wound healing by promoting vascularization in a diabetic foot ulcer rat model. Exp Mol Med 2018; 50:1–14. doi: 10.1038/s12276-018-0058-5. - PMC - PubMed

[5] Yang Y, Cai Y, Zhang Y, Liu J, Xu Z. Exosomes secreted by adipose-derived stem cells contribute to angiogenesis of brain microvascular endothelial cells following oxygen-glucose deprivation in vitro through microRNA-181b/TRPM7 axis. J Mol Neurosci 2018; 65:74–83. doi: 10.1007/s12031-018-1071-9. - PubMed

[6] Yang Y, Cai Y, Zhang Y, Liu J, Xu Z. Exosomes secreted by adipose-derived stem cells contribute to angiogenesis of brain microvascular endothelial cells following oxygen-glucose deprivation in vitro through microRNA-181b/TRPM7 axis. J Mol Neurosci 2018; 65:74–83. doi: 10.1007/s12031-018-1071-9. - PubMed

[7] An Y, Zhao J, Nie F, Qin Z, Xue H, Wang G, et al. . Exosomes from Adipose-Derived Stem Cells (ADSCs) overexpressing miR-21 promote vascularization of endothelial cells. Sci Rep 2019; 9:12861.doi: 10.1038/s41598-019-49339-y. - PMC - PubMed

[8] An Y, Zhao J, Nie F, Qin Z, Xue H, Wang G, et al. . Exosomes from Adipose-Derived Stem Cells (ADSCs) overexpressing miR-21 promote vascularization of endothelial cells. Sci Rep 2019; 9:12861.doi: 10.1038/s41598-019-49339-y. - PMC - PubMed

[9] Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M, Camussi G. Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun Signal 2014; 12:26.doi: 10.1186/1478-811X-12-26. - PMC - PubMed

[10] Lopatina T, Bruno S, Tetta C, Kalinina N, Porta M, Camussi G. Platelet-derived growth factor regulates the secretion of extracellular vesicles by adipose mesenchymal stem cells and enhances their angiogenic potential. Cell Commun Signal 2014; 12:26.doi: 10.1186/1478-811X-12-26. - PMC - PubMed

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Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications

Affiliations

Free-cell therapeutics and mechanism of exosomes from adipose-derived stem cells in promoting wound healing: current understanding and future applications

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Affiliations

Conflict of interest statement

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