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Review
. 2022 Mar 27;27(7):2165.
doi: 10.3390/molecules27072165.

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Md Rezaul Islam  1 , Fahadul Islam  1 , Mohamed H Nafady  2 , Muniya Akter  1 , Saikat Mitra  3 , Rajib Das  3 , Humaira Urmee  4 , Sheikh Shohag  5 , Aklima Akter  1 , Kumarappan Chidambaram  6 , Fahad A Alhumaydhi  7 , Talha Bin Emran  8 , Simona Cavalu  9
Affiliations
Review

Natural Small Molecules in Breast Cancer Treatment: Understandings from a Therapeutic Viewpoint

Md Rezaul Islam et al. Molecules. .

Abstract

Breast cancer (BrCa) is the most common malignancy in women and the second most significant cause of death from cancer. BrCa is one of the most challenging malignancies to treat, and it accounts for a large percentage of cancer-related deaths. The number of cases requiring more effective BrCa therapy has increased dramatically. Scientists are looking for more productive agents, such as organic combinations, for BrCa prevention and treatment because most chemotherapeutic agents are linked to cancer metastasis, the resistance of the drugs, and side effects. Natural compounds produced by living organisms promote apoptosis and inhibit metastasis, slowing the spread of cancer. As a result, these compounds may delay the spread of BrCa, enhancing survival rates and reducing the number of deaths caused by BrCa. Several natural compounds inhibit BrCa production while lowering cancer cell proliferation and triggering cell death. Natural compounds, in addition to therapeutic approaches, are efficient and potential agents for treating BrCa. This review highlights the natural compounds demonstrated in various studies to have anticancer properties in BrCa cells. Future research into biological anti-BrCa agents may pave the way for a new era in BrCa treatment, with natural anti-BrCa drugs playing a key role in improving BrCa patient survival rates.

Keywords: antitumor; breast cancer; combination therapy; immune-suppressive; natural compounds.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Molecular subtypes of breast cancer and triple-negative breast cancer types are depicted. Overall survival (for breast cancer subtypes) and relapse-free survival (for TNBC subtypes) are used to distinguish the subtypes.
Figure 2
Figure 2
Multifunctional effects of natural compounds on breast cancer.
See this image and copyright information in PMC

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