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Review
. 2022 Apr:75:102062.
doi: 10.1016/j.ceb.2022.01.007. Epub 2022 Mar 3.

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Simona Maria Migliano  1 , Eva Maria Wenzel  1 , Harald Stenmark  2
Affiliations
Free article
Review

Biophysical and molecular mechanisms of ESCRT functions, and their implications for disease

Simona Maria Migliano et al. Curr Opin Cell Biol. 2022 Apr.
Free article

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery evolved early in evolution to sculpt and cut cellular membranes. Consisting of three subcomplexes termed ESCRT-I, -II and -III, this machinery is recruited to various cellular locations to perform key steps in essential processes such as protein degradation, cell division, and membrane sealing. Here we review recent discoveries that have shed light on biophysical and molecular mechanisms of ESCRTs in endolysosomal protein degradation and nuclear envelope sealing, and we discuss how dysfunctional ESCRTs can lead to diseases such as cancer and neurodegenerative disorders.

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Conflict of interest statement

Conflict of interest statement Nothing declared.

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