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. 1986 Apr 11:376:221-33.

Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers

B Ríhová, J Kopecek, P Kopecková-Rejmanová, J Strohalm, D Plocová, H Semorádová
  • PMID: 3519635

Bioaffinity therapy with antibodies and drugs bound to soluble synthetic polymers

B Ríhová et al. J Chromatogr. .

Abstract

Soluble synthetic copolymers based on N-(2-hydroxypropyl)methacrylamide (HPMA) containing different oligopeptide side-sequences were tested as transport molecules for drugs and anti-Thy 1.2 antibodies in affinity therapy. As target cells, T lymphocytes were studied. (1) HPMA copolymers containing targeting anti-Thy 1.2 antibodies are 70 times more cytotoxic against T lymphocytes than HPMA copolymers with non-specific immunoglobulin. (2) Daunomycin conjugated to a biodegradable side-sequence (Gly-Phe-Leu-Gly) is effective in a concentration 100 times lower than daunomycin conjugated to a non-cleavable sequence (Gly-Gly). (3) HPMA copolymers containing drug and targeting antibodies are effective both in vitro and in vivo.

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