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Review
. 2021 Dec 1;207(11):2625-2630.
doi: 10.4049/jimmunol.2100829.

Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and Opportunities

Pushpa Tandon  1 , Natalie D Abrams  2 , Danielle M Carrick  2 , Preethi Chander  3 , Johanna Dwyer  4 , Rebecca Fuldner  5 , Gallya Gannot  6 , Maren Laughlin  7 , George McKie  8 , Mercy PrabhuDas  9 , Anju Singh  2 , Shang-Yi Anne Tsai  10 , Merriline M Vedamony  11 , Chiayeng Wang  2 , Christina H Liu  12
Affiliations
Review

Metabolic Regulation of Inflammation and Its Resolution: Current Status, Clinical Needs, Challenges, and Opportunities

Pushpa Tandon et al. J Immunol. .

Abstract

Metabolism and inflammation have been viewed as two separate processes with distinct but critical functions for our survival: metabolism regulates the utilization of nutrients, and inflammation is responsible for defense and repair. Both respond to an organism's stressors to restore homeostasis. The interplay between metabolic status and immune response (immunometabolism) plays an important role in maintaining health or promoting disease development. Understanding these interactions is critical in developing tools for facilitating novel preventative and therapeutic approaches for diseases, including cancer. This trans-National Institutes of Health workshop brought together basic scientists, technology developers, and clinicians to discuss state-of-the-art, innovative approaches, challenges, and opportunities to understand and harness immunometabolism in modulating inflammation and its resolution.

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Conflict of interest statement

Disclosures

The authors have no financial conflicts of interest.

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