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Review
. 2021 Nov 22;19(1):471.
doi: 10.1186/s12967-021-03143-3.

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Klaus J Wirth  1 , Carmen Scheibenbogen  2 , Friedemann Paul  3
Affiliations
Review

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Klaus J Wirth et al. J Transl Med. .

Erratum in

Abstract

There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow, increase in intracranial pressure and central adrenergic hyperactivity and how they can well explain the key symptoms of cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances and dysautonomia.

Keywords: Brain fog; Chronic Fatigue Syndrome; Cognitive impairment; Dysautonomia; Headache; Hypersensitivity; Myalgic Encephalomyelitis; Neurological symptoms; Post-Covid-19 syndrome; Sleep disturbance.

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Conflict of interest statement

The authors declares that they have no conflict of interests.

Figures

Fig. 1
Fig. 1
Key neurological pathomechanisms in ME/CFS
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