Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 Sep 1;166(3):625-36.
doi: 10.1084/jem.166.3.625.

A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene

Y Wang, A S Larsen, B M Peterlin

A tissue-specific transcriptional enhancer is found in the body of the HLA-DR alpha gene

Y Wang et al. J Exp Med. .

Abstract

We mapped cis-acting regulatory elements in the HLA-DR alpha gene, which encodes the monomorphic subunit of the HLA-DR heterodimer. Genomic fragments of HLA-DR alpha were placed 5' or 3' to the chloramphenicol acetyltransferase reporter gene, the transcription of which was initiated from the Herpes simplex thymidine kinase promoter. In transient expression assays, fragments from the body of the HLA-DR alpha gene were able to increase chloramphenicol acetyltransferase activity in a position-, orientation-, and promoter-independent yet tissue-specific fashion. These HLA-DR alpha cis-acting regulatory elements contain previously identified DNase I-hypersensitive sites and DNA sequences homologous to those found in other eukaryotic transcriptional enhancers.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Biochemistry. 1979 Nov 27;18(24):5294-9 - PubMed
    1. Immunol Rev. 1979;48:197-243 - PubMed
    1. Science. 1982 Jun 4;216(4550):1065-70 - PubMed
    1. Mol Cell Biol. 1982 Sep;2(9):1044-51 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jun;80(12):3543-7 - PubMed

Publication types