doi: 10.1073/pnas.83.22.8472.
Binding of ethidium bromide causes dissociation of the nucleosome core particle
- PMID: 3464964
- PMCID: PMC386952
- DOI: 10.1073/pnas.83.22.8472
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Binding of ethidium bromide causes dissociation of the nucleosome core particle
Proc Natl Acad Sci U S A.
1986 Nov.
Abstract
The binding of ethidium bromide to chicken erythrocyte core particles results in a step-wise dissociation of the structure that involves the initial release of one copy each of histones H2A and H2B. Quantitation of the dissociated DNA reveals that a critical amount of drug is required for the dissociation. Above the critical value, the dissociation is time dependent, reversible, and independent of DNA concentration.
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