Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

doi:10.3389/fcell.2021.686173

Review

. 2021 Jun 24:9:686173.

doi: 10.3389/fcell.2021.686173. eCollection 2021.

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Wuping Sun¹, Yixuan Luo², Fei Zhang², Shuo Tang³, Tao Zhu⁴

Affiliations

¹ Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
² Department of Cardiovascular Surgery, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
³ Department of Orthopaedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
⁴ Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

PMID: 34249940
PMCID: PMC8264417
DOI: 10.3389/fcell.2021.686173

Review

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Wuping Sun et al. Front Cell Dev Biol. 2021.

. 2021 Jun 24:9:686173.

doi: 10.3389/fcell.2021.686173. eCollection 2021.

Authors

Wuping Sun¹, Yixuan Luo², Fei Zhang², Shuo Tang³, Tao Zhu⁴

Affiliations

¹ Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
² Department of Cardiovascular Surgery, Shenzhen Nanshan People's Hospital and The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.
³ Department of Orthopaedics, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China.
⁴ Department of Respiratory Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

PMID: 34249940
PMCID: PMC8264417
DOI: 10.3389/fcell.2021.686173

Abstract

Obesity prevalence became a severe global health problem and it is caused by an imbalance between energy intake and expenditure. Brown adipose tissue (BAT) is a major site of mammalian non-shivering thermogenesis or energy dissipation. Thus, modulation of BAT thermogenesis might be a promising application for body weight control and obesity prevention. TRP channels are non-selective calcium-permeable cation channels mainly located on the plasma membrane. As a research focus, TRP channels have been reported to be involved in the thermogenesis of adipose tissue, energy metabolism and body weight regulation. In this review, we will summarize and update the recent progress of the pathological/physiological involvement of TRP channels in adipocyte thermogenesis. Moreover, we will discuss the potential of TRP channels as future therapeutic targets for preventing and combating human obesity and related-metabolic disorders.

Keywords: TRP channels; beige adipocytes; brown adipocytes; calcium; energy metabolism; obesity; thermogenesis.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

**FIGURE 1**
TRP channel-mediated adipocyte thermogenesis. A schematic figure of how TRPV1, TRPV2, TRPV4, TRPM8, and TRPC1-mediated calcium influx regulates thermogenic gene expression in adipocytes, which causes enhanced thermogenesis. Moreover, the increase in sympathetic nerve activity causes norepinephrine release from the sympathetic nerves and activation of β3-adrenergic receptor (β3ADR) in brown adipocytes, TRPV2 synergistically collaborated with β3ADR to involve in the regulation of peroxisome proliferator-activated receptor gamma coactivator-1 a (PGC1a) and uncoupling protein 1 (UCP1), subsequently enhances thermogenesis. On the other hand, TRPV4-mediated calcium influx negatively regulates thermogenic gene expression in adipocytes and subsequently inhibits thermogenesis.

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References

1. Ahuja K. D., Robertson I. K., Geraghty D. P., Ball M. J. (2006). Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am. J. Clin. Nutr. 84 63–69. - PubMed
1. Baboota R. K., Singh D. P., Sarma S. M., Kaur J., Sandhir R., Boparai R. K., et al. (2014). Capsaicin induces ”brite” phenotype in differentiating 3T3-L1 preadipocytes. PLoS One 9:e103093. 10.1371/journal.pone.0103093 - DOI - PMC - PubMed
1. Bautista D. M., Jordt S. E., Nikai T., Tsuruda P. R., Read A. J., Poblete J., et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124 1269–1282. 10.1016/j.cell.2006.02.023 - DOI - PubMed
1. Bertholet A. M., Kazak L., Chouchani E. T., Bogaczynska M. G., Paranjpe I., Wainwright G. L., et al. (2017). Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 25 811–822e814. 10.1016/j.cmet.2017.03.002 - DOI - PMC - PubMed
1. Bishnoi M., Khare P., Brown L., Panchal S. K. (2018). Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Obes. Rev. 19 1269–1292. 10.1111/obr.12703 - DOI - PubMed

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[1] Ahuja K. D., Robertson I. K., Geraghty D. P., Ball M. J. (2006). Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am. J. Clin. Nutr. 84 63–69. - PubMed

[2] Ahuja K. D., Robertson I. K., Geraghty D. P., Ball M. J. (2006). Effects of chili consumption on postprandial glucose, insulin, and energy metabolism. Am. J. Clin. Nutr. 84 63–69. - PubMed

[3] Baboota R. K., Singh D. P., Sarma S. M., Kaur J., Sandhir R., Boparai R. K., et al. (2014). Capsaicin induces ”brite” phenotype in differentiating 3T3-L1 preadipocytes. PLoS One 9:e103093. 10.1371/journal.pone.0103093 - DOI - PMC - PubMed

[4] Baboota R. K., Singh D. P., Sarma S. M., Kaur J., Sandhir R., Boparai R. K., et al. (2014). Capsaicin induces ”brite” phenotype in differentiating 3T3-L1 preadipocytes. PLoS One 9:e103093. 10.1371/journal.pone.0103093 - DOI - PMC - PubMed

[5] Bautista D. M., Jordt S. E., Nikai T., Tsuruda P. R., Read A. J., Poblete J., et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124 1269–1282. 10.1016/j.cell.2006.02.023 - DOI - PubMed

[6] Bautista D. M., Jordt S. E., Nikai T., Tsuruda P. R., Read A. J., Poblete J., et al. (2006). TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 124 1269–1282. 10.1016/j.cell.2006.02.023 - DOI - PubMed

[7] Bertholet A. M., Kazak L., Chouchani E. T., Bogaczynska M. G., Paranjpe I., Wainwright G. L., et al. (2017). Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 25 811–822e814. 10.1016/j.cmet.2017.03.002 - DOI - PMC - PubMed

[8] Bertholet A. M., Kazak L., Chouchani E. T., Bogaczynska M. G., Paranjpe I., Wainwright G. L., et al. (2017). Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metab. 25 811–822e814. 10.1016/j.cmet.2017.03.002 - DOI - PMC - PubMed

[9] Bishnoi M., Khare P., Brown L., Panchal S. K. (2018). Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Obes. Rev. 19 1269–1292. 10.1111/obr.12703 - DOI - PubMed

[10] Bishnoi M., Khare P., Brown L., Panchal S. K. (2018). Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy. Obes. Rev. 19 1269–1292. 10.1111/obr.12703 - DOI - PubMed

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Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Affiliations

Involvement of TRP Channels in Adipocyte Thermogenesis: An Update

Authors

Affiliations

Abstract

Conflict of interest statement

Figures

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Cited by

References

Publication types

LinkOut - more resources

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