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Review
. 2021 Jun 15;22(12):6392.
doi: 10.3390/ijms22126392.

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Nikita Suvorov  1 , Viktor Pogorilyy  1 , Ekaterina Diachkova  2 , Yuri Vasil'ev  3 , Andrey Mironov  1 , Mikhail Grin  1
Affiliations
Review

Derivatives of Natural Chlorophylls as Agents for Antimicrobial Photodynamic Therapy

Nikita Suvorov et al. Int J Mol Sci. .

Abstract

The rapid growth of drug-resistant bacteria all over the world has given rise to a major research challenge, namely a search for alternative treatments to which bacteria will be unable to develop resistance. Photodynamic therapy is an approach of this kind. It involves the use of photosensitizers in combination with visible light at a certain wavelength to excite the former and generate reactive oxygen species. Various synthetic heterocyclic compounds are used as photosensitizers. Of these, derivatives of natural chlorophylls have a special place due to their properties. This review deals with the use of such compounds in antimicrobial PDT.

Keywords: antimicrobial PDT; bacteriochlorophyll; chlorophyll; photodynamic therapy (PDT); photosensitizers (PS).

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chlorophyll a (1), chlorophyll b (2), bacteriochlorophyll a (3), and their absorption spectra.
Figure 2
Figure 2
Chlorophyll a derivatives used in antimicrobial PDT.
Figure 3
Figure 3
Cationic derivatives based on chlorins and heterocyclic compounds.
See this image and copyright information in PMC

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