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Randomized Controlled Trial
. 2021 Oct;20(10):3257-3263.
doi: 10.1111/jocd.14138. Epub 2021 Apr 20.

Objective assessment of Platelet-Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer

Yasser Helmy  1 , Nehal Farouk  2 , Asmaa Ali Dahy  3 , Ahmed Abu-Elsoud  4 , Rania Fouad Khattab  3 , Sahar Elshahat Mohammed  5 , Lamia Abdullbary Gad  5 , Ayman Altramsy  3 , Emad Hussein  3 , Ayman Farahat  1
Affiliations
Randomized Controlled Trial

Objective assessment of Platelet-Rich Plasma (PRP) potentiality in the treatment of Chronic leg Ulcer: RCT on 80 patients with Venous ulcer

Yasser Helmy et al. J Cosmet Dermatol. 2021 Oct.

Abstract

Background: Chronic venous leg ulcer reduces the patients' activities and their overall quality of life. Platelet-rich plasma (PRP) was previously investigated as promising less invasive management for leg ulcers.

This study aims: To re-assess the efficacy and safety of PRP in the management of chronic leg ulcers due to venous factors.

Patients/methods: RCT enrolled 80 patients who clinically presented with chronic venous leg ulcers. Forty patients were allocated randomly for the treatment with autologous platelet-rich plasma (PRP). Intradermal and subdermal injection of PRP by 27guage syringe weekly, in all edges and in the granular floor of the ulcer for 4-6 sessions. Another 40 patients managed by conventional treatment by compression and dressing for the same period were allocated as Group B. Objective assessment achieved by the percentage of reduction of the size of the ulcer area, rate of healing, incidence of recurrence, and if side effects have been reported.

Results: PRP therapy showed better results and high p value significance when compared to conventional therapy.

Conclusion: This study shows that PRP is effective and significant in promoting the wound healing process in chronic leg venous ulcers. PRP is simple, safe, and has a short learning curve technique.

Keywords: chronic ulcers; healing process; leg; platelet rich plasma; venous.

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