Six-month follow-up of gut microbiota richness in patients with COVID-19

doi:10.1136/gutjnl-2021-324090

Comment

. 2022 Jan;71(1):222-225.

doi: 10.1136/gutjnl-2021-324090. Epub 2021 Apr 8.

Six-month follow-up of gut microbiota richness in patients with COVID-19

Yanfei Chen^#¹, Silan Gu^#¹, Yunbo Chen¹, Haifeng Lu¹, Ding Shi¹, Jing Guo¹, Wen-Rui Wu¹, Ya Yang¹, Yongtao Li¹, Kai-Jin Xu¹, Cheng Ding¹, Rui Luo¹, Chenjie Huang¹, Ling Yu¹, Min Xu¹, Ping Yi², Jun Liu³, Jing-Jing Tao⁴, Hua Zhang¹, Longxian Lv⁴, Baohong Wang¹, Jifang Sheng¹, Lanjuan Li⁵

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesm, National Clinical Research Center for Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
² Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
³ National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesm, National Clinical Research Center for Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China ljli@zju.edu.cn.

^# Contributed equally.

PMID: 33833065
PMCID: PMC8666823
DOI: 10.1136/gutjnl-2021-324090

Comment

Six-month follow-up of gut microbiota richness in patients with COVID-19

Yanfei Chen et al. Gut. 2022 Jan.

. 2022 Jan;71(1):222-225.

doi: 10.1136/gutjnl-2021-324090. Epub 2021 Apr 8.

Authors

Affiliations

¹ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesm, National Clinical Research Center for Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
² Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang, China.
³ National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
⁴ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China.
⁵ State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseasesm, National Clinical Research Center for Infectious Diseases, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, Zhejiang, China ljli@zju.edu.cn.

^# Contributed equally.

PMID: 33833065
PMCID: PMC8666823
DOI: 10.1136/gutjnl-2021-324090

No abstract available

Keywords: COVID-19; intestinal microbiology.

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Conflict of interest statement

Competing interests: None declared.

Figures

**Figure 1**
Changes of faecal microbial communities in different stages (acute, convalescence, postconvalescence) of patients with COVID-19 (n=30), compared with uninfected controls (n=30). (A) α-Diversity, illustrated by microbiota richness (Chao 1 index), was reduced in COVID-19 (p<0.01, Wilcoxon rank-sum test). Boxes represent the 25th–75th percentile of the distribution; the median is shown as a thick line in the middle of the box; whiskers extend to values with 1.5 times the difference between the 25th and 75th percentiles. ***P<0.001. (B) Principal coordinate analysis (PCoA) of Bray-Curtis distance analysis demonstrated that the overall microbial composition of patients with COVID-19 deviated from the uninfected controls (analysis of similarities, R = – 0.201, p=0.001). (C) The same PCoA plot as (B), coloured by α-diversity measured by Chao 1 index.

See this image and copyright information in PMC

Comment on

Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19.
Yeoh YK, Zuo T, Lui GC, Zhang F, Liu Q, Li AY, Chung AC, Cheung CP, Tso EY, Fung KS, Chan V, Ling L, Joynt G, Hui DS, Chow KM, Ng SSS, Li TC, Ng RW, Yip TC, Wong GL, Chan FK, Wong CK, Chan PK, Ng SC. Yeoh YK, et al. Gut. 2021 Apr;70(4):698-706. doi: 10.1136/gutjnl-2020-323020. Epub 2021 Jan 11. Gut. 2021. PMID: 33431578 Free PMC article.

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References

1. Yeoh YK, Zuo T, GC-Y L. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 2021;70:698–706. - PMC - PubMed
1. Huang C, Huang L, Wang Y, et al. . 6-Month consequences of COVID-19 in patients discharged from Hospital: a cohort study. Lancet 2021;397:220–32. 10.1016/S0140-6736(20)32656-8 - DOI - PMC - PubMed
1. Nabavi N. Long covid: how to define it and how to manage it. BMJ 2020;370:m3489. 10.1136/bmj.m3489 - DOI - PubMed
1. Gu S, Chen Y, Wu Z. Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis 2020. - PMC - PubMed
1. Lahti L, Salojärvi J, Salonen A, et al. . Tipping elements in the human intestinal ecosystem. Nat Commun 2014;5:4344. 10.1038/ncomms5344 - DOI - PMC - PubMed

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[1] Yeoh YK, Zuo T, GC-Y L. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 2021;70:698–706. - PMC - PubMed

[2] Yeoh YK, Zuo T, GC-Y L. Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19. Gut 2021;70:698–706. - PMC - PubMed

[3] Huang C, Huang L, Wang Y, et al. . 6-Month consequences of COVID-19 in patients discharged from Hospital: a cohort study. Lancet 2021;397:220–32. 10.1016/S0140-6736(20)32656-8 - DOI - PMC - PubMed

[4] Huang C, Huang L, Wang Y, et al. . 6-Month consequences of COVID-19 in patients discharged from Hospital: a cohort study. Lancet 2021;397:220–32. 10.1016/S0140-6736(20)32656-8 - DOI - PMC - PubMed

[5] Nabavi N. Long covid: how to define it and how to manage it. BMJ 2020;370:m3489. 10.1136/bmj.m3489 - DOI - PubMed

[6] Nabavi N. Long covid: how to define it and how to manage it. BMJ 2020;370:m3489. 10.1136/bmj.m3489 - DOI - PubMed

[7] Gu S, Chen Y, Wu Z. Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis 2020. - PMC - PubMed

[8] Gu S, Chen Y, Wu Z. Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis 2020. - PMC - PubMed

[9] Lahti L, Salojärvi J, Salonen A, et al. . Tipping elements in the human intestinal ecosystem. Nat Commun 2014;5:4344. 10.1038/ncomms5344 - DOI - PMC - PubMed

[10] Lahti L, Salojärvi J, Salonen A, et al. . Tipping elements in the human intestinal ecosystem. Nat Commun 2014;5:4344. 10.1038/ncomms5344 - DOI - PMC - PubMed

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Six-month follow-up of gut microbiota richness in patients with COVID-19

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Six-month follow-up of gut microbiota richness in patients with COVID-19

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