Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Aug;32(8):968-982.
doi: 10.1016/j.annonc.2021.03.197. Epub 2021 Mar 24.

Oncolytic virus in gliomas: a review of human clinical investigations

A B Carpenter  1 , A M Carpenter  2 , R Aiken  3 , S Hanft  4
Affiliations
Free article
Review

Oncolytic virus in gliomas: a review of human clinical investigations

A B Carpenter et al. Ann Oncol. 2021 Aug.
Free article

Abstract

Gliomas remain one of the more frustrating targets for oncologic therapy. Glioma resistance to conventional therapeutics is a product of their immune-privileged milieu behind the blood-brain barrier, in addition to their suppressive effect on the immune response itself. Taking the lead from the growing success of immunotherapy for systemic cancers, such as lung cancer and melanoma, immunotherapeutics has emerged as a major player in the potential treatment of gliomas, with oncolytic viruses in particular showing significant promise as evidenced by the recent Breakthrough and Fast Tract Designations for PVSRIPO and DNX2401. This review serves as a useful and updated compendium of the completed human clinical investigations for several oncolytic viruses in the treatment of gliomas.

Keywords: glioma; immunotherapy; oncolytic virus.

PubMed Disclaimer

Conflict of interest statement

Disclosure The authors have declared no conflicts of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources