West African HIV-2-related human retrovirus with attenuated cytopathicity
- PMID: 3375832
- DOI: 10.1126/science.3375832
West African HIV-2-related human retrovirus with attenuated cytopathicity
Abstract
Clinical and seroepidemiological studies in West Africa indicate that human immunodeficiency virus type 2 (HIV-2) is widespread and associated with immunodeficiency states of variable degree. In this study, an isolate of HIV-2 from a patient in Senegal was molecularly cloned and characterized. This isolate (HIV-2ST) was shown by hybridization and restriction enzyme analysis to be more related to the prototype HIV-2ROD than to other human or primate retroviruses. Cultures of HIV-2ST showed genotypic polymorphism, and clones of the virus had transmembrane envelope glycoproteins of 30 and 42 kilodaltons. Unlike other immunodeficiency viruses, HIV-2ST did not cause cell death or induce cell fusion in peripheral blood lymphocytes or in any of four CD4+ cell lines tested. Although HIV-2ST entered cells by a CD4-dependent mechanism and replicated actively, cell-free transmission of the virus was retarded at the level of cell entry. These findings suggest that immunodeficiency viruses prevalent in West African populations are members of the HIV-2 virus group and that certain strains of this virus have attenuated virulence.
Similar articles
-
The env protein of an infectious noncytopathic HIV-2 is deficient in syncytium formation.AIDS Res Hum Retroviruses. 1990 Jun;6(6):707-20. doi: 10.1089/aid.1990.6.707. AIDS Res Hum Retroviruses. 1990. PMID: 2364016
-
Relation of HTLV-4 to simian and human immunodeficiency-associated viruses.Nature. 1987 Nov 12-18;330(6144):184-6. doi: 10.1038/330184a0. Nature. 1987. PMID: 2823148
-
Molecular cloning of two west African human immunodeficiency virus type 2 isolates that replicate well in macrophages: a Gambian isolate, from a patient with neurologic acquired immunodeficiency syndrome, and a highly divergent Ghanian isolate.Proc Natl Acad Sci U S A. 1989 Apr;86(7):2383-7. doi: 10.1073/pnas.86.7.2383. Proc Natl Acad Sci U S A. 1989. PMID: 2467304 Free PMC article.
-
The origins of HIV-1 and HTLV-4/HIV-2.Ann N Y Acad Sci. 1987;511:370-5. doi: 10.1111/j.1749-6632.1987.tb36265.x. Ann N Y Acad Sci. 1987. PMID: 2894192 Review.
-
Retroviral etiology of the acquired immune deficiency syndrome (AIDS).AIDS Res. 1986 Dec;2 Suppl 1:S35-48. AIDS Res. 1986. PMID: 2881556 Review.
Cited by
-
Lack of effect of cytoplasmic tail truncations on human immunodeficiency virus type 2 ROD env particle release activity.J Virol. 1999 Jan;73(1):778-82. doi: 10.1128/JVI.73.1.778-782.1999. J Virol. 1999. PMID: 9847387 Free PMC article.
-
Pathogenesis of human immunodeficiency virus infection.Microbiol Rev. 1993 Mar;57(1):183-289. doi: 10.1128/mr.57.1.183-289.1993. Microbiol Rev. 1993. PMID: 8464405 Free PMC article. Review.
-
HIV-2 inhibits HIV-1 gene expression via two independent mechanisms during cellular co-infection.J Virol. 2023 Dec 21;97(12):e0187022. doi: 10.1128/jvi.01870-22. Epub 2023 Nov 22. J Virol. 2023. PMID: 37991365 Free PMC article.
-
Identification of a novel retroviral gene unique to human immunodeficiency virus type 2 and simian immunodeficiency virus SIVMAC.J Virol. 1988 Sep;62(9):3501-5. doi: 10.1128/JVI.62.9.3501-3505.1988. J Virol. 1988. PMID: 3136256 Free PMC article.
-
Localization of immunogenic domains in the human immunodeficiency virus type 2 envelope.J Virol. 1991 Sep;65(9):5073-9. doi: 10.1128/JVI.65.9.5073-5079.1991. J Virol. 1991. PMID: 1714524 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
