The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

doi:10.3390/tropicalmed6010016

Review

. 2021 Jan 26;6(1):16.

doi: 10.3390/tropicalmed6010016.

The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

Eric Dumonteil¹, Claudia Herrera¹

Affiliations

Affiliation

¹ Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

PMID: 33530605
PMCID: PMC7851737
DOI: 10.3390/tropicalmed6010016

Review

The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

Eric Dumonteil et al. Trop Med Infect Dis. 2021.

. 2021 Jan 26;6(1):16.

doi: 10.3390/tropicalmed6010016.

Authors

Eric Dumonteil¹, Claudia Herrera¹

Affiliation

¹ Department of Tropical Medicine, Vector-Borne and Infectious Disease Research Center, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA 70112, USA.

PMID: 33530605
PMCID: PMC7851737
DOI: 10.3390/tropicalmed6010016

Abstract

Chagas disease is a major neglected tropical disease, transmitted predominantly by triatomine insect vectors, but also through congenital and oral routes. While endemic in the Americas, it has turned into a global disease. Because of the current drug treatment limitations, a vaccine would represent a major advancement for better control of the disease. Here, we review some of the rationale, advances, and challenges for the ongoing development of a vaccine against Chagas disease. Recent pre-clinical studies in murine models have further expanded (i) the range of vaccine platforms and formulations tested; (ii) our understanding of the immune correlates for protection; and (iii) the extent of vaccine effects on cardiac function, beyond survival and parasite burden. We further discuss outstanding issues and opportunities to move Chagas disease development forward in the near future.

Keywords: Trypanosoma cruzi; Trypanosomiasis; neglected tropical disease; parasite.

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Conflict of interest statement

The authors have no conflict of interest.

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Borgna E, Prochetto E, Gamba JC, Vermeulen EM, Poncini CV, Cribb P, Pérez AR, Marcipar I, González FB, Cabrera G. Borgna E, et al. Front Immunol. 2024 Nov 1;15:1484290. doi: 10.3389/fimmu.2024.1484290. eCollection 2024. Front Immunol. 2024. PMID: 39555082 Free PMC article.
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Dumonteil E, Tu W, Desale H, Goff K, Marx P, Ortega-Lopez J, Herrera C. Dumonteil E, et al. Res Sq [Preprint]. 2023 Nov 2:rs.3.rs-3453582. doi: 10.21203/rs.3.rs-3453582/v1. Res Sq. 2023. Update in: J Biomed Sci. 2024 Jun 1;31(1):58. doi: 10.1186/s12929-024-01050-5. PMID: 37961272 Free PMC article. Updated. Preprint.
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References

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1. Arnal A., Waleckx E., Rico-Chavez O., Herrera C., Dumonteil E. Estimating the current burden of Chagas disease in Mexico: A systematic review and meta-analysis of epidemiological surveys from 2006 to 2017. PLoS Negl. Trop. Dis. 2019;13:e0006859. doi: 10.1371/journal.pntd.0006859. - DOI - PMC - PubMed
1. Buekens P., Lopez-Cardenas J., Dumonteil E., Padilla-Raygoza N. Including unpublished surveys in reviews on Chagas disease in Mexico. Publ. Health Rev. 2020;41:24. doi: 10.1186/s40985-020-00140-7. - DOI - PMC - PubMed

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[1] Rassi A., Jr., Rassi A., Marin-Neto J.A. Chagas disease. Lancet. 2010;375:1388–1402. doi: 10.1016/S0140-6736(10)60061-X. - DOI - PubMed

[2] Rassi A., Jr., Rassi A., Marin-Neto J.A. Chagas disease. Lancet. 2010;375:1388–1402. doi: 10.1016/S0140-6736(10)60061-X. - DOI - PubMed

[3] Schmunis G.A., Yadon Z.E. Chagas disease: A Latin American health problem becoming a world health problem. Acta Trop. 2010;115:14–21. doi: 10.1016/j.actatropica.2009.11.003. - DOI - PubMed

[4] Schmunis G.A., Yadon Z.E. Chagas disease: A Latin American health problem becoming a world health problem. Acta Trop. 2010;115:14–21. doi: 10.1016/j.actatropica.2009.11.003. - DOI - PubMed

[5] WHO Chagas disease in Latin America: An epidemiological update based on 2010 estimates. Wkly. Epidemiol. Rec. 2015;90:33–43. - PubMed

[6] WHO Chagas disease in Latin America: An epidemiological update based on 2010 estimates. Wkly. Epidemiol. Rec. 2015;90:33–43. - PubMed

[7] Arnal A., Waleckx E., Rico-Chavez O., Herrera C., Dumonteil E. Estimating the current burden of Chagas disease in Mexico: A systematic review and meta-analysis of epidemiological surveys from 2006 to 2017. PLoS Negl. Trop. Dis. 2019;13:e0006859. doi: 10.1371/journal.pntd.0006859. - DOI - PMC - PubMed

[8] Arnal A., Waleckx E., Rico-Chavez O., Herrera C., Dumonteil E. Estimating the current burden of Chagas disease in Mexico: A systematic review and meta-analysis of epidemiological surveys from 2006 to 2017. PLoS Negl. Trop. Dis. 2019;13:e0006859. doi: 10.1371/journal.pntd.0006859. - DOI - PMC - PubMed

[9] Buekens P., Lopez-Cardenas J., Dumonteil E., Padilla-Raygoza N. Including unpublished surveys in reviews on Chagas disease in Mexico. Publ. Health Rev. 2020;41:24. doi: 10.1186/s40985-020-00140-7. - DOI - PMC - PubMed

[10] Buekens P., Lopez-Cardenas J., Dumonteil E., Padilla-Raygoza N. Including unpublished surveys in reviews on Chagas disease in Mexico. Publ. Health Rev. 2020;41:24. doi: 10.1186/s40985-020-00140-7. - DOI - PMC - PubMed

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The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

Affiliation

The Case for the Development of a Chagas Disease Vaccine: Why? How? When?

Authors

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Conflict of interest statement

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