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Review
. 2021 Jun;39(3):986-1006.
doi: 10.1007/s12640-020-00323-9. Epub 2021 Jan 5.

Peroxisomes of the Brain: Distribution, Functions, and Associated Diseases

Rachayeeta Deb  1 , Neha Joshi  1 , Shirisha Nagotu  2
Affiliations
Review

Peroxisomes of the Brain: Distribution, Functions, and Associated Diseases

Rachayeeta Deb et al. Neurotox Res. 2021 Jun.

Abstract

Peroxisomes are versatile cell organelles that exhibit a repertoire of organism and cell-type dependent functions. The presence of oxidases and antioxidant enzymes is a characteristic feature of these organelles. The role of peroxisomes in various cell types in human health and disease is under investigation. Defects in the biogenesis of the organelle and its function lead to severe debilitating disorders. In this manuscript, we discuss the distribution and functions of peroxisomes in the nervous system and especially in the brain cells. The important peroxisomal functions in these cells and their role in the pathology of associated disorders such as neurodegeneration are highlighted in recent studies. Although the cause of the pathogenesis of these disorders is still not clearly understood, emerging evidence supports a crucial role of peroxisomes. In this review, we discuss research highlighting the role of peroxisomes in brain development and its function. We also provide an overview of the major findings in recent years that highlight the role of peroxisome dysfunction in various associated diseases.

Keywords: Brain; Nervous system; Neurodegeneration; Peroxisome biogenesis disorders; Peroxisomes.

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