doi: 10.1016/0002-9343(87)90918-1.
Cardiac immunoglobulin deposition in congenital heart block associated with maternal anti-Ro autoantibodies
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- PMID: 3314497
- DOI: 10.1016/0002-9343(87)90918-1
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Cardiac immunoglobulin deposition in congenital heart block associated with maternal anti-Ro autoantibodies
Am J Med.
1987 Oct.
Abstract
Isolated congenital complete heart block is frequently found in offspring of mothers who have IgG anti-Ro/SSA autoantibodies. IgG deposition was reported in the heart of a baby who died from heart block and heart failure. The pattern of antibody deposition observed was the same as that reproduced in animal models for anti-Ro/SSA binding. The IgG deposition was present in, but not limited to, the conduction system. Scattered small infiltrates of mononuclear cells and a limited, patchy deposition of complement were also observed. These findings support the possibility that isolated congenital heart block may be causally related to autoantibodies.
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