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Review
. 2020 Oct 12:2020:2360872.
doi: 10.1155/2020/2360872. eCollection 2020.

Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation

Sandro Percário  1 , Aline da Silva Barbosa  1 , Everton Luiz Pompeu Varela  1 , Antônio Rafael Quadros Gomes  1 , Michelli Erica Souza Ferreira  1 , Thayana de Nazaré Araújo Moreira  1 , Maria Fani Dolabela  2
Affiliations
Review

Oxidative Stress in Parkinson's Disease: Potential Benefits of Antioxidant Supplementation

Sandro Percário et al. Oxid Med Cell Longev. .

Abstract

Parkinson's disease (PD) occurs in approximately 1% of the population over 65 years of age and has become increasingly more common with advances in age. The number of individuals older than 60 years has been increasing in modern societies, as well as life expectancy in developing countries; therefore, PD may pose an impact on the economic, social, and health structures of these countries. Oxidative stress is highlighted as an important factor in the genesis of PD, involving several enzymes and signaling molecules in the underlying mechanisms of the disease. This review presents updated data on the involvement of oxidative stress in the disease, as well as the use of antioxidant supplements in its therapy.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Sources of oxidative stress in Parkinson's disease.
Figure 2
Figure 2
Mechanisms of free radical involvement in Parkinson's disease.
See this image and copyright information in PMC

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