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Review
. 2020 Sep 18:11:2089.
doi: 10.3389/fimmu.2020.02089. eCollection 2020.

Mumps Outbreaks in Vaccinated Populations-Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Anna R Connell  1 , Jeff Connell  2 , T Ronan Leahy  3   4 , Jaythoon Hassan  1   2
Affiliations
Review

Mumps Outbreaks in Vaccinated Populations-Is It Time to Re-assess the Clinical Efficacy of Vaccines?

Anna R Connell et al. Front Immunol. .

Abstract

History illustrates the remarkable public health impact of mass vaccination, by dramatically improving life expectancy and reducing the burden of infectious diseases and co-morbidities worldwide. It has been perceived that if an individual adhered to the MMR vaccine schedule that immunity to mumps virus (MuV) would be lifelong. Recent mumps outbreaks in individuals who had received two doses of the Measles Mumps Rubella (MMR) vaccine has challenged the efficacy of the MMR vaccine. However, clinical symptoms, complications, viral shedding and transmission associated with mumps infection has been shown to be reduced in vaccinated individuals, demonstrating a benefit of this vaccine. Therefore, the question of what constitutes a good mumps vaccine and how its impact is assessed in this modern era remains to be addressed. Epidemiology of the individuals most affected by the outbreaks (predominantly young adults) and variance in the circulating MuV genotype have been well-described alluding to a collection of influences such as vaccine hesitancy, heterogeneous vaccine uptake, primary, and/or secondary vaccine failures. This review aims to discuss in detail the interplay of factors thought to be contributing to the current mumps outbreaks seen in highly vaccinated populations. In addition, how mumps diagnoses has progressed and impacted the understanding of mumps infection since a mumps vaccine was first developed, the limitations of current laboratory tests in confirming protection in vaccinated individuals and how vaccine effectiveness is quantified are also considered. By highlighting knowledge gaps within this area, this state-of-the-art review proposes a change of perspective regarding the impact of a vaccine in a highly vaccinated population from a clinical, diagnostic and public perspective, highlighting a need for a paradigm shift on what is considered vaccine immunity.

Keywords: immunity; mumps outbreaks; protection; vaccinated populations; vaccine efficacy.

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Figure 1
Figure 1
Current perspectives on recent mumps outbreaks seen in vaccinated populations (blue circles). How impactful a vaccine is defined may lead to a paradigm shift in what constitutes an effective vaccine.
See this image and copyright information in PMC

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References

    1. Hviid A, Rubin S, Muhlemann K. Mumps. Lancet. (2008) 371:932–44. 10.1016/S0140-6736(08)60419-5 - DOI - PubMed
    1. Cantell K. Mumps virus. Adv Virus Res. (1961) 8:123–64. 10.1016/S0065-3527(08)60684-3 - DOI - PubMed
    1. Narita M, Matsuzono Y, Takekoshi Y, Yamada S, Itakura O, Kubota M, et al. . Analysis of mumps vaccine failure by means of avidity testing for mumps virus-specific immunoglobulin G. Clin Diagn Lab Immunol. (1998) 5:799–803. 10.1128/CDLI.5.6.799-803.1998 - DOI - PMC - PubMed
    1. Simpson RE. Infectiousness of communicable diseases in the household (measles, chickenpox, and mumps). Lancet. (1952) 2:549–54. 10.1016/S0140-6736(52)91357-3 - DOI - PubMed
    1. Hall R, Richards H. Hearing loss due to mumps. Arch Dis Child. (1987) 62:189–91. 10.1136/adc.62.2.189 - DOI - PMC - PubMed

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