COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
- PMID: 32998157
- DOI: 10.1038/s41586-020-2814-7
COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses
Erratum in
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Publisher Correction: COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses.Nature. 2021 Feb;590(7844):E17. doi: 10.1038/s41586-020-03102-w. Nature. 2021. PMID: 33469214 No abstract available.
Abstract
An effective vaccine is needed to halt the spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic. Recently, we reported safety, tolerability and antibody response data from an ongoing placebo-controlled, observer-blinded phase I/II coronavirus disease 2019 (COVID-19) vaccine trial with BNT162b1, a lipid nanoparticle-formulated nucleoside-modified mRNA that encodes the receptor binding domain (RBD) of the SARS-CoV-2 spike protein1. Here we present antibody and T cell responses after vaccination with BNT162b1 from a second, non-randomized open-label phase I/II trial in healthy adults, 18-55 years of age. Two doses of 1-50 μg of BNT162b1 elicited robust CD4+ and CD8+ T cell responses and strong antibody responses, with RBD-binding IgG concentrations clearly above those seen in serum from a cohort of individuals who had recovered from COVID-19. Geometric mean titres of SARS-CoV-2 serum-neutralizing antibodies on day 43 were 0.7-fold (1-μg dose) to 3.5-fold (50-μg dose) those of the recovered individuals. Immune sera broadly neutralized pseudoviruses with diverse SARS-CoV-2 spike variants. Most participants had T helper type 1 (TH1)-skewed T cell immune responses with RBD-specific CD8+ and CD4+ T cell expansion. Interferon-γ was produced by a large fraction of RBD-specific CD8+ and CD4+ T cells. The robust RBD-specific antibody, T cell and favourable cytokine responses induced by the BNT162b1 mRNA vaccine suggest that it has the potential to protect against COVID-19 through multiple beneficial mechanisms.
Comment in
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Steroid-responsive aseptic meningitis after BNT162b2 SARS-CoV-2 vaccine.Rev Neurol (Paris). 2022 Jan-Feb;178(1-2):160-161. doi: 10.1016/j.neurol.2021.10.002. Epub 2021 Nov 4. Rev Neurol (Paris). 2022. PMID: 34799078 Free PMC article. No abstract available.
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