Lack of evidence for BCG vaccine protection from severe COVID-19

doi:10.1073/pnas.2016733117

Comment

. 2020 Oct 13;117(41):25203-25204.

doi: 10.1073/pnas.2016733117. Epub 2020 Sep 29.

Lack of evidence for BCG vaccine protection from severe COVID-19

Cecilia S Lindestam Arlehamn¹, Alessandro Sette^{1

2}, Bjoern Peters^{3

2}

Affiliations

¹ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037.
² Department of Medicine, University of California San Diego, La Jolla, CA 92093.
³ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037; bpeters@lji.org.

PMID: 32994350
PMCID: PMC7568270
DOI: 10.1073/pnas.2016733117

Comment

Lack of evidence for BCG vaccine protection from severe COVID-19

Cecilia S Lindestam Arlehamn et al. Proc Natl Acad Sci U S A. 2020.

. 2020 Oct 13;117(41):25203-25204.

doi: 10.1073/pnas.2016733117. Epub 2020 Sep 29.

Authors

Cecilia S Lindestam Arlehamn¹, Alessandro Sette^{1

2}, Bjoern Peters^{3

2}

Affiliations

¹ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037.
² Department of Medicine, University of California San Diego, La Jolla, CA 92093.
³ Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA 92037; bpeters@lji.org.

PMID: 32994350
PMCID: PMC7568270
DOI: 10.1073/pnas.2016733117

No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interest.

Figures

**Fig. 1.**
Association between percentage of vaccination coverage and maximum COVID-19 deaths per million inhabitants registered by country. Log₁₀ deaths per million inhabitants vs. percentage of bacillus Calmette–Guérin vaccination coverage. Data from April 22, 2020, blue dots and line (Pearson r = 0.46, P = 0.0006), and data from August 1, 2020, orange dots and line (Pearson r = 0.2, P = 0.16).

**Fig. 2.**
COVID-19 mortality rates correlates with the frequency of alpine skiers in different German states. Frequency of Alpine skiers was taken from ref. , and COVID-19 mortality in different German states was taken from ref. , excluding city states and the Saarland.

See this image and copyright information in PMC

Comment in

Reply to Patella et al. and Lindestam Arlehamn et al.: Complex pandemic dynamics and effect of bacillus Calmette-Guérin (BCG) vaccination on COVID-19 prevalence and mortality.
Barillas-Mury C, Escobar LE, Molina-Cruz A. Barillas-Mury C, et al. Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25207-25208. doi: 10.1073/pnas.2017197117. Epub 2020 Sep 29. Proc Natl Acad Sci U S A. 2020. PMID: 32994348 Free PMC article. No abstract available.

Comment on

BCG vaccine protection from severe coronavirus disease 2019 (COVID-19).
Escobar LE, Molina-Cruz A, Barillas-Mury C. Escobar LE, et al. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):17720-17726. doi: 10.1073/pnas.2008410117. Epub 2020 Jul 9. Proc Natl Acad Sci U S A. 2020. PMID: 32647056 Free PMC article.

Cited by

Efficacy and outcomes of BCG re-vaccination in COVID-19: a systematic review, meta-analysis, and meta-regression of randomized controlled trials.
Jain H, Odat RM, Hussein AM, Dey D, Ahmed M, Jain J, Goyal A, Ratnani T, Idrees M, Prajjwal P, Passey S, Yadav R. Jain H, et al. Ann Med Surg (Lond). 2024 Jul 17;86(9):5439-5446. doi: 10.1097/MS9.0000000000002370. eCollection 2024 Sep. Ann Med Surg (Lond). 2024. PMID: 39239021 Free PMC article. Review.
BCG administration promotes the long-term protection afforded by a single-dose intranasal adenovirus-based SARS-CoV-2 vaccine.
Perera DJ, Domenech P, Babuadze GG, Naghibosadat M, Alvarez F, Koger-Pease C, Labrie L, Stuible M, Durocher Y, Piccirillo CA, Lametti A, Fiset PO, Elahi SM, Kobinger GP, Gilbert R, Olivier M, Kozak R, Reed MB, Ndao M. Perera DJ, et al. iScience. 2023 Aug 11;26(9):107612. doi: 10.1016/j.isci.2023.107612. eCollection 2023 Sep 15. iScience. 2023. PMID: 37670783 Free PMC article.
The role of trained immunity in COVID-19: Lessons for the next pandemic.
Netea MG, Ziogas A, Benn CS, Giamarellos-Bourboulis EJ, Joosten LAB, Arditi M, Chumakov K, van Crevel R, Gallo R, Aaby P, van der Meer JWM. Netea MG, et al. Cell Host Microbe. 2023 Jun 14;31(6):890-901. doi: 10.1016/j.chom.2023.05.004. Cell Host Microbe. 2023. PMID: 37321172 Free PMC article. Review.
Mycobacterium tuberculosis and SARS-CoV-2 co-infections: The knowns and unknowns.
Chiok KR, Dhar N, Banerjee A. Chiok KR, et al. iScience. 2023 May 19;26(5):106629. doi: 10.1016/j.isci.2023.106629. Epub 2023 Apr 8. iScience. 2023. PMID: 37091987 Free PMC article. Review.
Efficacy of BCG Vaccination against COVID-19: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Wen J, Liu Q, Tang D, He JQ. Wen J, et al. J Clin Med. 2023 Feb 1;12(3):1154. doi: 10.3390/jcm12031154. J Clin Med. 2023. PMID: 36769802 Free PMC article. Review.

See all "Cited by" articles

References

1. Escobar L. E., Molina-Cruz A., Barillas-Mury C., BCG vaccine protection from severe coronavirus disease 2019 (COVID-19). Proc. Natl. Acad. Sci. U.S.A. 117, 17720–17726 (2020). - PMC - PubMed
1. Johns Hopkins University , Coronavirus Resource Center. https://coronavirus.jhu.edu/. Accessed 1 August 2020.
1. Aaby P. et al. ., Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period? J. Infect. Dis. 204, 245–252 (2011). - PubMed
1. Biering-Sørensen S. et al. ., Early BCG-Denmark and neonatal mortality among infants weighing <2500 g: A randomized controlled trial. Clin. Infect. Dis. 65, 1183–1190 (2017). - PMC - PubMed
1. Nemes E. et al. .; C-040-404 Study Team , Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination. N. Engl. J. Med. 379, 138–149 (2018). - PMC - PubMed

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

Grants and funding

U19 AI118626/AI/NIAID NIH HHS/United States

LinkOut - more resources

Full Text Sources

[1] Escobar L. E., Molina-Cruz A., Barillas-Mury C., BCG vaccine protection from severe coronavirus disease 2019 (COVID-19). Proc. Natl. Acad. Sci. U.S.A. 117, 17720–17726 (2020). - PMC - PubMed

[2] Escobar L. E., Molina-Cruz A., Barillas-Mury C., BCG vaccine protection from severe coronavirus disease 2019 (COVID-19). Proc. Natl. Acad. Sci. U.S.A. 117, 17720–17726 (2020). - PMC - PubMed

[3] Johns Hopkins University , Coronavirus Resource Center. https://coronavirus.jhu.edu/. Accessed 1 August 2020.

[4] Johns Hopkins University , Coronavirus Resource Center. https://coronavirus.jhu.edu/. Accessed 1 August 2020.

[5] Aaby P. et al. ., Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period? J. Infect. Dis. 204, 245–252 (2011). - PubMed

[6] Aaby P. et al. ., Randomized trial of BCG vaccination at birth to low-birth-weight children: beneficial nonspecific effects in the neonatal period? J. Infect. Dis. 204, 245–252 (2011). - PubMed

[7] Biering-Sørensen S. et al. ., Early BCG-Denmark and neonatal mortality among infants weighing <2500 g: A randomized controlled trial. Clin. Infect. Dis. 65, 1183–1190 (2017). - PMC - PubMed

[8] Biering-Sørensen S. et al. ., Early BCG-Denmark and neonatal mortality among infants weighing <2500 g: A randomized controlled trial. Clin. Infect. Dis. 65, 1183–1190 (2017). - PMC - PubMed

[9] Nemes E. et al. .; C-040-404 Study Team , Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination. N. Engl. J. Med. 379, 138–149 (2018). - PMC - PubMed

[10] Nemes E. et al. .; C-040-404 Study Team , Prevention of M. tuberculosis infection with H4:IC31 vaccine or BCG revaccination. N. Engl. J. Med. 379, 138–149 (2018). - PMC - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Lack of evidence for BCG vaccine protection from severe COVID-19

Affiliations

Lack of evidence for BCG vaccine protection from severe COVID-19

Authors

Affiliations

Conflict of interest statement

Figures

Comment in

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Conflict of interest statement

Figures

Comment in

Comment on

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources