Seasonal coronavirus protective immunity is short-lasting

doi:10.1038/s41591-020-1083-1

. 2020 Nov;26(11):1691-1693.

doi: 10.1038/s41591-020-1083-1. Epub 2020 Sep 14.

Seasonal coronavirus protective immunity is short-lasting

Arthur W D Edridge¹, Joanna Kaczorowska¹, Alexis C R Hoste², Margreet Bakker¹, Michelle Klein¹, Katherine Loens^{3

4}, Maarten F Jebbink¹, Amy Matser⁵, Cormac M Kinsella¹, Paloma Rueda², Margareta Ieven³, Herman Goossens^{3

4}, Maria Prins^{5

6}, Patricia Sastre², Martin Deijs¹, Lia van der Hoek⁷

Affiliations

¹ Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
² INGENASA, Inmunología y Genética Aplicada S. A., Madrid, Spain.
³ Department of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Wilrijk, Belgium.
⁴ Department of Microbiology, University Hospital Antwerp, Edegem, Belgium.
⁵ Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands.
⁶ Amsterdam UMC, University of Amsterdam, Department of Infectious Diseases, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
⁷ Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. c.m.vanderhoek@amsterdamumc.nl.

PMID: 32929268
DOI: 10.1038/s41591-020-1083-1

Free article

Seasonal coronavirus protective immunity is short-lasting

Arthur W D Edridge et al. Nat Med. 2020 Nov.

Free article

. 2020 Nov;26(11):1691-1693.

doi: 10.1038/s41591-020-1083-1. Epub 2020 Sep 14.

Authors

Affiliations

¹ Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
² INGENASA, Inmunología y Genética Aplicada S. A., Madrid, Spain.
³ Department of Medical Microbiology, Vaccine & Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Wilrijk, Belgium.
⁴ Department of Microbiology, University Hospital Antwerp, Edegem, Belgium.
⁵ Department of Infectious Diseases, Public Health Service of Amsterdam, Amsterdam, the Netherlands.
⁶ Amsterdam UMC, University of Amsterdam, Department of Infectious Diseases, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
⁷ Laboratory of Experimental Virology, Department of Medical Microbiology and Infection Prevention, Amsterdam Infection & Immunity Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. c.m.vanderhoek@amsterdamumc.nl.

PMID: 32929268
DOI: 10.1038/s41591-020-1083-1

Abstract

A key unsolved question in the current coronavirus disease 2019 (COVID-19) pandemic is the duration of acquired immunity. Insights from infections with the four seasonal human coronaviruses might reveal common characteristics applicable to all human coronaviruses. We monitored healthy individuals for more than 35 years and determined that reinfection with the same seasonal coronavirus occurred frequently at 12 months after infection.

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References

1. Pyrc, K. et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J. Mol. Biol. 364, 964–973 (2006). - DOI
1. Callow, K. A., Parry, H. F., Sergeant, M. & Tyrrell, D. A. J. The time course of the immune response to experimental coronavirus infection of man. Epidemiol. Infect. 105, 435–446 (1990). - DOI
1. Van Bilsen, W. P. H. et al. Diverging trends in incidence of HIV versus other sexually transmitted infections in HIV-negative MSM in Amsterdam. AIDS 34, 301–309 (2020). - DOI
1. Blanchard, E. G., Miao, C., Haupt, T. E., Anderson, L. J. & Haynes, L. M. Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43. J. Virol. Methods 177, 100–106 (2011). - DOI
1. Li, Y., Wang, X. & Nair, H. Global seasonality of human seasonal coronaviruses: a clue for postpandemic circulating season of severe acute respiratory syndrome coronavirus 2? J. Infect. Dis. 222, 1090–1097 (2020).

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[1] Pyrc, K. et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J. Mol. Biol. 364, 964–973 (2006). - DOI

[2] Pyrc, K. et al. Mosaic structure of human coronavirus NL63, one thousand years of evolution. J. Mol. Biol. 364, 964–973 (2006). - DOI

[3] Callow, K. A., Parry, H. F., Sergeant, M. & Tyrrell, D. A. J. The time course of the immune response to experimental coronavirus infection of man. Epidemiol. Infect. 105, 435–446 (1990). - DOI

[4] Callow, K. A., Parry, H. F., Sergeant, M. & Tyrrell, D. A. J. The time course of the immune response to experimental coronavirus infection of man. Epidemiol. Infect. 105, 435–446 (1990). - DOI

[5] Van Bilsen, W. P. H. et al. Diverging trends in incidence of HIV versus other sexually transmitted infections in HIV-negative MSM in Amsterdam. AIDS 34, 301–309 (2020). - DOI

[6] Van Bilsen, W. P. H. et al. Diverging trends in incidence of HIV versus other sexually transmitted infections in HIV-negative MSM in Amsterdam. AIDS 34, 301–309 (2020). - DOI

[7] Blanchard, E. G., Miao, C., Haupt, T. E., Anderson, L. J. & Haynes, L. M. Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43. J. Virol. Methods 177, 100–106 (2011). - DOI

[8] Blanchard, E. G., Miao, C., Haupt, T. E., Anderson, L. J. & Haynes, L. M. Development of a recombinant truncated nucleocapsid protein based immunoassay for detection of antibodies against human coronavirus OC43. J. Virol. Methods 177, 100–106 (2011). - DOI

[9] Li, Y., Wang, X. & Nair, H. Global seasonality of human seasonal coronaviruses: a clue for postpandemic circulating season of severe acute respiratory syndrome coronavirus 2? J. Infect. Dis. 222, 1090–1097 (2020).

[10] Li, Y., Wang, X. & Nair, H. Global seasonality of human seasonal coronaviruses: a clue for postpandemic circulating season of severe acute respiratory syndrome coronavirus 2? J. Infect. Dis. 222, 1090–1097 (2020).

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Seasonal coronavirus protective immunity is short-lasting

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Seasonal coronavirus protective immunity is short-lasting

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