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Review
. 2014 Jul:1:25-30.
doi: 10.1016/j.cois.2014.04.001. Epub 2014 May 2.

Evolutionary insights into DNA methylation in insects

Karl M Glastad  1 , Brendan G Hunt  2 , Michael Ad Goodisman  3
Affiliations
Review

Evolutionary insights into DNA methylation in insects

Karl M Glastad et al. Curr Opin Insect Sci. 2014 Jul.

Abstract

Epigenetic information affects gene function and plays a critical role in development. DNA methylation is one of the most widespread epigenetic marks and has been linked to developmental plasticity in insects. Here, we review the patterns and functions of DNA methylation in insects. We specifically focus on how the application of an evolutionary framework has led to important insights into the role of DNA methylation. We discuss the importance of evolutionary variation in DNA methylation among insect taxa and show how comparative analyses have revealed conservation in targets of DNA methylation. We then show how the distribution of DNA methylation in insect genomes has been linked to evolutionary conserved patterns of histone modifications and variants. We conclude by discussing how the evolutionary conservation and variability of DNA methylation in insects can provide insight into the function of DNA methylation across eukaryotic systems.

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