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Case Reports
. 2020 Jul 16:7:388.
doi: 10.3389/fmed.2020.00388. eCollection 2020.

Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report

Novella Carannante  1   2 , Giuseppe Fiorentino  1   2 , Antonio Corcione  1   2 , Raffaele Di Sarno  1   2 , Micaela Spatarella  1   2 , Nicola Maturo  1   2 , Fiorentino Fragranza  1   2 , Pierpaolo Di Micco  1   2
Affiliations
Case Reports

Administration of Immunoglobulins in SARS-CoV-2-Positive Patient Is Associated With Fast Clinical and Radiological Healing: Case Report

Novella Carannante et al. Front Med (Lausanne). .

Abstract

Polyclonal preparation of IgM as an adjuvant therapy has been reported as a relevant immunomodulant therapy in several infectious diseases, exhibiting, in most cases, improvement of the clinical course. No drug has demonstrated therapeutic efficacy for COVID-19. Immunomodulatory treatment with hydroxychloroquine and biologics as tocilizumab, in fact, has not proven to show satisfactory results in several reports. We therefore treated a selected patient with interstitial multifocal pneumonia, positive to COVID-19, with polyclonal preparation of immunoglobulins as an adjuvant therapy, obtaining in few days clinical remission and improvements in radiological findings. Based on this case report, we suggest that clinical trials are conducted to test the efficacy and safety of polyclonal immunoglobulins for adjunctive therapy of COVID-19.

Keywords: COVID 19; PENTAGLOBIN; SARS-CoV2; case report; immunoglobulin; pneumonia.

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Figures

Figure 1
Figure 1
Lung CT scan with evidence of multifocal pneaumonia.
Figure 2
Figure 2
Lung CT scan after treatment with pneumonia resolution.
See this image and copyright information in PMC

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